Evidence map›Paper›PMID 39893429›Full record

ArticleBMC genomics2025

Comparative transcriptomic and metabolomics analysis of ovary in Nilaparvata lugens after trehalase inhibition.

Yongkang Liu, Fan Yang, Sijing Wan, Xianzhong Wang, Liwen Guan, Yan Li, Caidi Xu, Binghua Xie, Shigui Wang, Xiao-Ling Tan and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yongkang Liu *College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P.R. China.
Fan Yang *College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P.R. China.
Sijing WanCollege of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P.R. China.
Xianzhong WangCollege of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P.R. China.
Liwen GuanCollege of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P.R. China.
Yan LiCollege of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P.R. China.
Caidi XuChinese Education Modernization Research Institute of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P.R. China.
Binghua XieCollege of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P.R. China.
Shigui WangCollege of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P.R. China.
Xiao-Ling TanState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, P.R. China. tanxiaoling@caas.cn.
Bin TangCollege of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, 311121, P.R. China. tbzm611@hznu.edu.cn.

Funding

ADOPT- IPM project 101060430National Key R & D Program of China 2023YFE0104800National Natural Science Foundation of China No.32272608
6 · The paper itself

Abstract

The fecundity of Nilaparvata lugens (brown planthopper) is influenced by trehalase (TRE). To investigate the mechanism by which trehalose affects the reproduction of N. lugens, we conducted a comparative transcriptomic and metabolomic analysis of the ovaries of N. lugens following injection with dsTREs and validamycin (a TRE inhibitor). The results revealed that 844 differentially expressed genes (DEGs) were identified between the dsGFP and dsTREs injection groups, with 317 up-regulated genes and 527 down-regulated genes. Additionally, 1451 DEGs were identified between the water and validamycin injection groups, with 637 up-regulated genes and 814 down-regulated genes. The total number of DEGs identified between the two comparison groups was 236. The overlapping DEGs were implicated in various biological processes, including protein metabolism, fatty acid metabolism, AMPK signaling, mTOR signaling, insulin/insulin-like growth factor signaling (IIS), the tricarboxylic acid (TCA) cycle, oxidative phosphorylation, and the cellular process of meiosis in oocytes. These results suggest that the inhibition of TRE expression may lead to alterations in ovarian nutrient and energy metabolism by modulating glucose transport and affecting amino acid metabolic pathways. These alterations may influence the reproduction of N. lugens by modulating reproductive regulatory signals. These findings provide robust evidence supporting the mechanism through which trehalase inhibition reduces the reproductive capacity of N. lugens.

Indexed as

HemipteraInsect ProteinsMetabolomicsOvaryTranscriptomeTrehalaseAnimalsFemaleGene Expression ProfilingInositolMetabolomeInositolInsect ProteinsTrehalasevalidamycin AMetabolomicsNilaparvata lugensOvary developmentTranscriptomicTrehalase

Identifiers

PMID39893429
PMCPMC11787742

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.