Evidence map›Paper›PMID 39893419›Full record

ReviewJournal of nanobiotechnology2025

Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics.

Anmei Chen, Ying Gong, Shaoquan Wu, Ye Du, Zhijun Liu, Yuhong Jiang, Jiahong Li, Yang-Bao Miao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
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  4. Article
  5. Article
  6. Review
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  11. Review
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  13. Polydopamine-chitosan coated biofilm-stateMaterials today. Bio · 2025
    Article
  14. New advances in oral microbiology and tumor research.World journal of clinical oncology · 2025
    Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anmei ChenSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610041, China.
Ying GongSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610041, China.
Shaoquan WuSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610041, China.
Ye DuSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610041, China.
Zhijun LiuUrology Institute of Shenzhen University, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, 518000, China.
Yuhong JiangSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610041, China. yuhong.jiang@swjtu.edu.cn.
Jiahong LiSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610041, China. jiahongljh@163.com.
Yang-Bao MiaoDepartment of Haematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, No. 32, West Section 2, First Ring Road, Qingyang District, Chengdu, 610000, China. miaoyangbao@uestc.edu.cn.

Funding

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital 30420220004Sichuan Province Science and Technology Activities Funding for Returned Overseas Scholars noneSichuan Science and Technology Program 24GJHZ0072Starting Research Fund from the National Natural Science Foundation of China 32401173
6 · The paper itself

Abstract

Oral probiotics have significant potential for preventing and treating many diseases. Yet, their efficacy is often hindered by challenges related to survival and colonization within the gastrointestinal tract. Nanoparticles emerge as a transformative solution, offering robust protection and enhancing the stability and bioavailability of these probiotics. This review explores the innovative application of nanoparticle-armored engineered probiotics for precise disease treatment, specifically addressing the physiological barriers associated with oral administration. A comprehensive evaluation of various nano-armor probiotics and encapsulation methods is provided, carefully analyzing their respective merits and limitations, alongside strategies to enhance probiotic survival and achieve targeted delivery and colonization within the gastrointestinal tract. Furthermore, the review explores the potential clinical applications of nano-armored probiotics in precision therapeutics, critically addressing safety and regulatory considerations, and proposing the innovative concept of 'probiotic intestinal colonization with nano armor' for brain-targeted therapies. Ultimately, this review aspires to guide the advancement of nano-armored probiotic therapies, driving progress in precision medicine and paving the way for groundbreaking treatment modalities.

Indexed as

NanoparticlesPrecision MedicineProbioticsAdministration, OralAnimalsGastrointestinal MicrobiomeGastrointestinal TractHumansGut to brainNanoparticlesOral administrationPrecision therapyProbiotics

Identifiers

PMID39893419
PMCPMC11786591

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.