Evidence map›Paper›PMID 39893414›Full record

ArticleBMC microbiology2025

Effect of Candida albicans' supernatant on biofilm formation and virulence factors of Pseudomonas aeruginosa through las/rhl System.

Ke Zhang, Yingying Huang, Yuting Jiang, Tangjuan Liu, Jinliang Kong, Shuangqi Cai, Zhongwei Wen, Yiqiang Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ke Zhang *Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Qingxiu District, Nanning City, Guangxi Zhuang Autonomous Region, 530021, China.
Yingying Huang *Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Qingxiu District, Nanning City, Guangxi Zhuang Autonomous Region, 530021, China.
Yuting Jiang *Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Qingxiu District, Nanning City, Guangxi Zhuang Autonomous Region, 530021, China.
Tangjuan LiuDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Qingxiu District, Nanning City, Guangxi Zhuang Autonomous Region, 530021, China.
Jinliang KongDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Qingxiu District, Nanning City, Guangxi Zhuang Autonomous Region, 530021, China.
Shuangqi CaiDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Qingxiu District, Nanning City, Guangxi Zhuang Autonomous Region, 530021, China.
Zhongwei WenDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Qingxiu District, Nanning City, Guangxi Zhuang Autonomous Region, 530021, China.
Yiqiang ChenDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Qingxiu District, Nanning City, Guangxi Zhuang Autonomous Region, 530021, China. chenyiq0708@163.com.

Funding

Guangxi Zhuang Autonomous Region Health Commission self funded research project Z20190940National Natural Science Foundation of China 81760743Open Project of Guangxi Key Laboratory of Regenerative Medicine GUIZAICHONGKAI 202206Open Project of Key Laboratory of Longevity and Aging-related Diseases (Guangxi Medical University), Ministry of Education KLLAD202204
6 · The paper itself

Abstract

Pseudomonas aeruginosa (P. aeruginosa) and Candida albicans (C. albicans) are opportunistic pathogens whose mixed infections can exacerbate microbial dissemination and drug resistance, contributing to high mortality and morbidity rates among infected individuals. Few studies have explored the impact of C. albicans supernatant on P. aeruginosa, and the underlying mechanisms of such mixed infections remain unclear. In this study, we investigated the effects of C. albicans supernatant on biofilm formation and virulence factor activity in wild-type P. aeruginosa PAO1 and its quorum sensing-deficient mutants, ΔlasIrhlI and ΔlasRrhlR. Our results demonstrated that the biofilm formation capability and virulence were significantly higher in the PAO1 group compared to the ΔlasIrhlI and ΔlasRrhlR groups. Furthermore, exposure to C. albicans supernatant significantly enhanced both the biofilm formation and virulence of PAO1, whereas no significant changes were observed in the ΔlasIrhlI and ΔlasRrhlR mutants relative to their respective controls. These findings suggest that C. albicans supernatant may modulate P. aeruginosa biofilm formation and virulence via the las/rhl quorum sensing system.

Indexed as

Bacterial ProteinsBiofilmsCandida albicansPseudomonas aeruginosaTrans-ActivatorsVirulence FactorsQuorum SensingVirulenceBacterial ProteinsTrans-ActivatorsVirulence FactorsbiofilmCandida albicanslas/rhl systemPseudomonas aeruginosavirulence

Identifiers

PMID39893414
PMCPMC11786564

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.