Evidence map›Paper›PMID 39893320›Full record

ArticleCommunications biology2025

Evidence from a mouse model supports repurposing an anti-asthmatic drug, bambuterol, against Alzheimer's disease by administration through an intranasal route.

Anne-Claire Groo, Thomas Curel, Aurélie Malzert-Fréon, Line Séguy, Ophélie Bento, Sophie Corvaisier, Thomas Culerier, Romain Legrand, Noëlle Callizot, Alexandre Henriques and 4 more

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Implication of Central βArchiv der Pharmazie · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anne-Claire Groo *Université de Caen Normandie, CERMN UR4258, Normandie Univ, 14000, Caen, France.
Thomas Curel *IGF, Univ. Montpellier, CNRS, INSERM, F-34094, Montpellier, France.
Aurélie Malzert-FréonUniversité de Caen Normandie, CERMN UR4258, Normandie Univ, 14000, Caen, France.ORCID http://orcid.org/0000-0001-6023-1861
Line SéguyUniversité de Caen Normandie, CERMN UR4258, Normandie Univ, 14000, Caen, France.
Ophélie BentoIGF, Univ. Montpellier, CNRS, INSERM, F-34094, Montpellier, France.ORCID http://orcid.org/0000-0002-7857-1642
Sophie CorvaisierUniversité de Caen Normandie, CERMN UR4258, Normandie Univ, 14000, Caen, France.
Thomas CulerierUniversité de Caen Normandie, CERMN UR4258, Normandie Univ, 14000, Caen, France.
Romain LegrandRONOMA Pharma, 31 rue Léon Delille, F-76800, Saint Etienne du Rouvray, France.
Noëlle CallizotNeuro-Sys, 410 chemin départemental 60, F-13120, Gardanne, France.
Alexandre HenriquesNeuro-Sys, 410 chemin départemental 60, F-13120, Gardanne, France.
Georgia CulleyNeuro-Sys, 410 chemin départemental 60, F-13120, Gardanne, France.
Sylvie ClaeysenIGF, Univ. Montpellier, CNRS, INSERM, F-34094, Montpellier, France.ORCID http://orcid.org/0000-0002-0576-5518
Christophe RochaisUniversité de Caen Normandie, CERMN UR4258, Normandie Univ, 14000, Caen, France. christophe.rochais@unicaen.fr.ORCID http://orcid.org/0000-0001-7996-2082
Patrick DallemagneUniversité de Caen Normandie, CERMN UR4258, Normandie Univ, 14000, Caen, France. patrick.dallemagne@unicaen.fr.ORCID http://orcid.org/0000-0002-4845-615X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bambuterol is a long-acting anti-asthmatic prodrug which releases terbutaline. Terbutaline is an agonist of the β

Indexed as

Alzheimer DiseaseAnti-Asthmatic AgentsDrug RepositioningTerbutalineAdministration, IntranasalAmyloid beta-PeptidesAnimalsDisease Models, AnimalHippocampusMaleMiceNeuronsNeuroprotective AgentsRatsAmyloid beta-PeptidesAnti-Asthmatic AgentsbambuterolNeuroprotective AgentsTerbutaline

Identifiers

PMID39893320
PMCPMC11787381

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.