SynthesisNeuropsychology review2025
Noninvasive Brain Stimulation in Primary Progressive Aphasia with and Without Concomitant Speech and Language Therapy: Systematic Review and Meta-analysis.
Synthesis in Neuropsychology review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- A multi-modal approach for the treatment of non-fluent/agrammatic variant of Primary Progressive Aphasia.Brain communications · 2025Trial
- Article
- Non-invasive brain stimulation in frontotemporal dementia: syndrome-specific signals and priorities for future trials.Frontiers in aging neuroscience · 2026Review
- Non-inferiority of Accelerated vs. Repetitive Transcranial Magnetic Stimulation in Major Depressive Disorder: A Systematic Review.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Review
- Efficacy of Transcranial Magnetic Stimulation and Transcranial Direct-Current Stimulation in Primary Progressive Aphasia Treatment: A Review.Brain sciences · 2025Review
- Personalized Language Training and Bi-Hemispheric tDCS Improve Language Connectivity in Chronic Aphasia: A fMRI Case Study.Journal of personalized medicine · 2025Article
- Feasibility of Home-Based Transcranial Direct Current Stimulation with Telerehabilitation in Primary Progressive Aphasia-A Case Series.Brain sciences · 2025Article
- Safety and Efficacy of Different Therapeutic Interventions for Primary Progressive Aphasia: A Systematic Review.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary progressive aphasias (PPA) represent a group of neurodegenerative conditions affecting verbal communication abilities for which no effective medication is currently available. Noninvasive brain stimulation (NiBS) has been mainly explored as adjunctive therapy to conventional speech and language therapy (SLT) with promising results. The present meta-analysis of randomized-controlled trials (RCTs) aims to evaluate the efficacy of NiBS in PPA patients on a range of linguistic tasks (naming, phonemic fluency, semantic fluency). A literature search was carried out using EMBASE and PUBMED, searching for multi-session RCTs administering NiBS on PPA patients as stand-alone or with SLT. The results were not significant overall, indicating a null difference between the active and the sham condition on language functions; pooled effects tended to be higher in parallel than in crossover studies and for follow-ups than post-treatment. In the naming analyses, the combined effects for the studies that coupled NiBS with SLT were slightly higher than the overall effect at each time point, although not significant. These results need to be considered with caution given the low number of included studies and small sample sizes, but offer relevant indications for future research in terms of optimal treatment protocols and personalization of therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.