Evidence map›Paper›PMID 39893201›Full record

ArticleNature communications2025

Distal protein-protein interactions contribute to nirmatrelvir resistance.

Eric M Lewandowski, Xiujun Zhang, Haozhou Tan, Aiden Jaskolka-Brown, Navita Kohaal, Aliaksandra Frazier, Jesper J Madsen, Lian M C Jacobs, Jun Wang, Yu Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Eric M Lewandowski *Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.ORCID http://orcid.org/0000-0001-6235-6502
Xiujun Zhang *Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Haozhou Tan *Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, USA.
Aiden Jaskolka-BrownDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Navita KohaalDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Aliaksandra FrazierDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Jesper J MadsenDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.ORCID http://orcid.org/0000-0003-1411-9080
Lian M C JacobsDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Jun WangDepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, USA. junwang@pharmacy.rutgers.edu.ORCID http://orcid.org/0000-0002-4845-4621
Yu ChenDepartment of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. ychen1@usf.edu.ORCID http://orcid.org/0000-0002-5115-3600

Funding

Development of dual inhibitors targeting the viral main protease and the host cathepsin L as SARS-CoV-2 antiviralsR01AI158775 · NIAID · UNIVERSITY OF ARIZONA · PI Jun Wang · 2021 to 2026
$3.6M
NIAID NIH HHS R01 AI158775U.S. Department of Health & Human Services | National Institutes of Health (NIH) AI158775
6 · The paper itself

Abstract

SARS-CoV-2 main protease, M

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesCOVID-19 Drug TreatmentDrug Resistance, ViralSARS-CoV-2Catalytic DomainCOVID-19HumansMutationProtein BindingVirus Replication3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C Proteases

Identifiers

PMID39893201
PMCPMC11787374

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.