Evidence map›Paper›PMID 39893014›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2025

Platelet spreading and clot retraction are regulated by 2 distinct α

Arjit Nigam, Voddarahally N Manjuprasanna, Meghna U Naik, Ulhas P Naik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Arjit NigamDepartment of Biological Sciences, University of Delaware, Newark, Delaware.
Voddarahally N ManjuprasannaCardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.
Meghna U NaikCardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.
Ulhas P NaikCardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematologic Research, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address: ulhas.naik@jefferson.edu.

Funding

Endogenous suppression of integrin signalingR01HL119374 · NHLBI · UNIVERSITY OF DELAWARE · PI NAIK, ULHAS P · 2013 to 2022
$3.8M
ASK1 a novel regulator of platelet functionR01HL113188 · NHLBI · UNIVERSITY OF DELAWARE · PI NAIK, ULHAS P · 2013 to 2022
$3.4M
Third Coast HIV-Related Cardiovascular and Sleep Disorders K12 Career Development ProgramK12HL143959 · NHLBI · UNIVERSITY OF CHICAGO · PI ARDEHALI, HOSSEIN, SCHNEIDER, JOHN · 2018 to 2022
$1.5M
NHLBI NIH HHS K12 HL143959NHLBI NIH HHS R01 HL113188NHLBI NIH HHS R01 HL119374
6 · The paper itself

Abstract

Bidirectional signaling through platelet integrin α

Indexed as

Blood PlateletsClot RetractionPlatelet Glycoprotein GPIIb-IIIa ComplexSignal TransductionHumansPlatelet ActivationPlatelet Glycoprotein GPIIb-IIIa ComplexClot retractionIntegrin α(IIb)β3PlateletsPlatelet spreadingSignaling

Identifiers

PMID39893014
PMCPMC13632521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.