Observational studyJournal of pediatric and adolescent gynecology2025
An Intervention to Increase Fertility Preservation Counseling Prior to Starting Gender-Affirming Hormone Therapy.
Observational study in Journal of pediatric and adolescent gynecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Rapid review of gender-affirming healthcare for children and adolescents: Evidence synthesis (2021-2025) and recommendations for South Africa.Southern African journal of HIV medicine · 2026Review
- Rapid Review of Gender-Affirming Healthcare for Children and Adolescents: Evidence Synthesis (2021-2025) and Recommendations for South Africa.Research square · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeTo determine if an educational handout regarding fertility preservation options affected rates of fertility preservation counseling, REI referrals, and gamete cryopreservation in transgender and nonbinary adolescents.
methodsThis was a retrospective observational pre/post intervention study of patients seen at a single academic gender-affirming care clinic and were prescribed gender-affirming hormone therapy from January 2022 to January 2023 and April 2023 to April 2024. EXPOSURE: Educational handout.
main outcome measuresThe primary outcome was the rate of fertility preservation counseling.
resultsThere were 208 eligible patients, with 143 in the pre-intervention group and 65 in the post-intervention group. There was a significant increase in fertility preservation counseling rates after implementing the educational handout (31.5% counseling rate pre-intervention vs 58.46% post-intervention, percentage change 26.9%, SE 7.3%, P < .001). Of the patients counseled on fertility preservation, there was no significant difference in REI referral rates (percentage change -3.2%, SE 6.5%, P = .6208) or in gamete cryopreservation. DISCUSSION: Increased access to educational materials increases the rate of fertility preservation counseling in transgender and nonbinary adolescents. More research is needed to determine how to improve resources and empower adolescents and their families to make informed decisions regarding reproductive health. IMPLICATIONS AND CONTRIBUTION: Clinicians who provide gender-affirming medical care should be equipped with educational resources they can offer their patients. Increased education and counseling may assist patients in making an informed decision regarding their fertility, regardless of whether or not they choose to preserve their fertility.
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Registered trials
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