ArticleBiological psychiatry2025
Investigating the Contribution of Coding Variants in Alcohol Use Disorder Using Whole-Exome Sequencing Across Ancestries.
Article in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Review
- Genotype-by-sex interaction analyses for alcohol use disorder across biobanks.Alcohol, clinical & experimental research · 2025Article
- Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants.Translational psychiatry · 2025Article
- Genome Variation in Alcohol Use Disorder by Whole-Exome Sequencing.Addiction biology · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundAlcohol use disorder (AUD) is a leading cause of death and disability worldwide. There has been substantial progress in identifying genetic variants that underlie AUD. However, whole-exome sequencing studies of AUD have been hampered by the lack of available samples.
methodsWe analyzed whole-exome sequencing data of 4530 samples from the Yale-Penn cohort and 469,835 samples from the UK Biobank, which represent an unprecedented resource for exploring the contribution of coding variants in AUD. After quality control, 1750 African-ancestry (1142 cases) and 2039 European-ancestry (1420 cases) samples from the Yale-Penn and 6142 African-ancestry (130 cases), 415,617 European-ancestry (12,861 cases), and 4607 South Asian (130 cases) samples from the UK Biobank cohorts were included in the analyses.
resultsWe confirmed the well-known functional variant rs1229984 in ADH1B (p = 4.88 × 10
conclusionsThis study extends our understanding of the genetic architecture of AUD by providing insights into the contribution of rare coding variants, separately and convergently with common variants in AUD.
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