Evidence map›Paper›PMID 39892305›Full record

ReviewPsychiatry research2025

Follicle-stimulating hormone: More than a marker for menopause: FSH as a frontier for women's mental health.

Julie Spicer, Dolores Malaspina, Stephanie V Blank, Ki A Goosens

Abstract readReview
In one paragraph

Review in Psychiatry research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. SheVari4Food & nutrition research · 2026
    Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Julie SpicerDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Center for Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: julie.spicer@mssm.edu.
Dolores MalaspinaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Center for Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Stephanie V BlankDepartment of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Ki A GoosensDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Center for Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Funding

Hormonal Drivers of Perimenopausal Inflammation and Mood SymptomsR01MH135079 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Julie A Spicer · 2024 to 2026
$2.8M
NIMH NIH HHS R01 MH135079
6 · The paper itself

Abstract

The average current life expectancy entails that women will spend over one-third of their lives in menopause. Follicle-stimulating hormone (FSH) levels in women begin to increase roughly six years before the final menstrual period, reaching a menopausal plateau that is nearly 14 times the level of FSH observed in men, a profound sex-specific difference. A promising new body of work examines whether these age-associated increases in FSH contribute to multiple menopause-related conditions, including psychiatric morbidities. This paper highlights research advances showing the potential role of FSH and its underlying mechanisms in mental health conditions for women in menopause and makes the call for more research.

Indexed as

Follicle Stimulating HormoneMenopauseMental DisordersMental HealthWomen's HealthBiomarkersFemaleHumansBiomarkersFollicle Stimulating HormoneAgingAnxietyDepressionFSHMenopauseMood symptomsOophorectomy

Identifiers

PMID39892305
PMCPMC12094525

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.