Evidence map›Paper›PMID 39891829›Full record

ArticleNeurochemical research2025

Long Noncoding RNA ISA1 Protects Against Ischemic Brain Damage by Promoting the Transformation of Microglia Toward Anti-inflammatory Phenotype via the SOCS3/JAK2/STAT3 Pathway.

Ermei Lu, Peng Zhou, Yuanyuan Li, Jiale Chen, Kexin Zhang, Kecheng Zhou

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ermei Lu *Department of Pharmacy, The Dingli Clinical College of Wenzhou Medical University, Wenzhou Central Hospital, Zhejiang, 325000, Wenzhou, China.
Peng Zhou *Institute of Neuroscience, Basic Medical College of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yuanyuan LiRehabilitation Medicine Center, The Second Affliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jiale ChenRehabilitation Medicine Center, The Second Affliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Kexin ZhangRehabilitation Medicine Center, The Second Affliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Kecheng ZhouRehabilitation Medicine Center, The Second Affliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. zhou_kc@126.com.

Funding

Basic Research Program of Wenzhou City Y2020194National Natural Science Foundation of China 82003976Zhejiang Provincial Natural Science Foundation of China LQ21H280008Zhejiang Traditional Chinese Medicine Science and Technology Plan 2021ZB182
6 · The paper itself

Abstract

The shift of microglia towards an anti-inflammatory phenotype has been shown to decrease neuroinflammation, improve neurological function, and is considered a potential therapeutic approach for stroke. Abnormal expression of multiple long noncoding RNA (LncRNA) has been discovered to be crucially related to the pathogenesis progress of ischemic brain injury. Here we concentrated on a novel LncRNA NR_037961.1, which we named ischemic stroke associated LncRNA1 (LncRNA ISA1). The expression of LncRNA ISA1 was notably decreased in brain tissue of middle cerebral artery occlusion (MCAO) mice. Overexpression of LncRNA ISA1 decreases cerebral infarction and brain edema, and improves cerebral blood flow and neurological outcome, promoting recovery of MCAO mice. Additionally, the neuroprotective effects that LncRNA ISA1 plays on MCAO mice are mediated by encouraging the transformation of microglia toward anti-inflammatory phenotype and alleviating neuroinflammation. LncRNA ISA1 facilitates the phenotypic transformation of microglia, closely linked to its promotion of SOCS3 expression and subsequent inhibition of the JAK2/STAT3 signaling pathway. Furthermore, downregulation of SOCS3 eliminated the effects of LncRNA ISA1 on transformation of microglia to anti-inflammatory phenotype. Our results indicate that LncRNA ISA1 promotes the anti-inflammatory polarization of microglia via regulation of the SOCS3/JAK2/STAT3 signaling pathway, and contributes to its neuroprotective effects in ischemic stroke.

Indexed as

Brain IschemiaMicrogliaRNA, Long NoncodingSuppressor of Cytokine Signaling 3 ProteinAnimalsInfarction, Middle Cerebral ArteryJanus Kinase 2MaleMiceMice, Inbred C57BLPhenotypeSignal TransductionSTAT3 Transcription FactorJak2 protein, mouseJanus Kinase 2RNA, Long NoncodingSocs3 protein, mouseStat3 protein, mouseSTAT3 Transcription FactorSuppressor of Cytokine Signaling 3 ProteinIschemic strokeLong noncoding RNAMicroglia polarizationNeuroinflammationSOCS3

Identifiers

PMID39891829

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.