Detecting mild cognitive impairment by applying integrated random forest to finger tapping.

Early detection of dementia is essential to reduce the decline in quality of life (QoL) and the increase in medical and nursing care costs associated with dementia in an aging society. In this study, we aimed to develop a simple screening test for mild cognitive impairment (MCI), a preliminary stage of dementia, by creating an analytical method to accurately detect MCI through finger-tapping measurement. We extracted 248 characteristics from the finger-tapping waveforms of 182 MCI patients and 352 normal controls, applying five conventional classification methods along with an improved Random Forest (RF) method proposed in this study (Integrated RF). In the proposed method, the RF classification model for the MCI and normal control groups is supplementally integrated with the RF classification model for the Alzheimer's disease and normal control groups to generate a new classification model. When comparing the discrimination accuracy of each method, the proposed method achieved the highest accuracy, with an F1-score of 0.795 (recall = 0.778 and precision = 0.814). These results demonstrate the potential of finger-tapping measurement as a highly accurate screening test for MCI.