Characterization of facial nerve outcomes following radiosurgery for vestibular schwannoma: a meta-analysis.

Gabrielle E A Hovis, Anubhav Chandla, Aryan Pandey, Zoe Teton, Isaac Yang

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Synthesis in Acta neurochirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Gabrielle E A HovisDepartment of 1Neurosurgery, UCLA Medical Center, Harbor, Los Angeles, CA, USA.

Anubhav ChandlaDepartment of 1Neurosurgery, UCLA Medical Center, Harbor, Los Angeles, CA, USA.

Aryan PandeyDepartment of 1Neurosurgery, UCLA Medical Center, Harbor, Los Angeles, CA, USA.

Zoe TetonDepartment of 1Neurosurgery, UCLA Medical Center, Harbor, Los Angeles, CA, USA.

Isaac YangDepartment of 1Neurosurgery, UCLA Medical Center, Harbor, Los Angeles, CA, USA. iyang@mednet.ucla.edu.ORCID 0000-0003-3744-5110

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6 · The paper itself

Abstract

purposeGamma Knife radiosurgery (GKRS) is a precise and efficacious treatment modality for vestibular schwannoma (VS) with favorable cranial nerve preservation rates. This study aims to better characterize facial nerve (FN) outcomes in VS after GKRS.

methodsA query of six medical databases was conducted following PRISMA guidelines. Eligible studies exclusively reported VS managed with single-fraction GKRS and included House-Brackmann (HB) scale assessments prior to and following GKRS. Data was analyzed using random-effects modeling, and FN preservation was defined as HB I or II at last follow-up.

resultsData was analyzed from 15 articles with 3,155 patients at an mean age of 55.0 years. Mean tumor volume, radiation dose, follow-up, tumor control, and hearing preservation were 4.28 cm

conclusionThis meta-analysis identifies tumor volume and radiation dose as prognostic factors for FN preservation. A FN preservation rate of 93% may be expected at five years after GKRS. This study provides a unique characterization of FN outcome that should be considered in the management of VS.

Indexed as

Facial NerveFacial Nerve InjuriesNeuroma, AcousticRadiosurgeryHumansMiddle AgedTreatment OutcomeFacial nerve preservationGamma knifeRadiosurgeryVestibular schwannoma

Identifiers

PMID39891778

DOI10.1007/s00701-024-06405-3

PMCPMC11787209

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