Evidence map›Paper›PMID 39891645›Full record

ReviewThe Journal of investigative dermatology2025

Designing and Evaluating Circadian Experiments on Mouse Skin.

Junyan Duan, Satya Swaroop Karri, Kiarash Forouzesh, Thomas Mortimer, Maksim V Plikus, Salvador Aznar Benitah, Joseph S Takahashi, Bogi Andersen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of investigative dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junyan DuanCenter for Complex Biological Systems, University of California, Irvine, Irvine, California, USA; The NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, California, USA.
Satya Swaroop KarriDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California, USA; Division of Endocrinology, Department of Medicine, School of Medicine, University of California, Irvine, Irvine, California, USA.
Kiarash ForouzeshDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California, USA; Division of Endocrinology, Department of Medicine, School of Medicine, University of California, Irvine, Irvine, California, USA.
Thomas MortimerInstitute for Research in Biomedicine, The Barcelona Institute of Science and Technology, Barcelona, Spain.
Maksim V PlikusCenter for Complex Biological Systems, University of California, Irvine, Irvine, California, USA; The NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, California, USA; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, California, USA.
Salvador Aznar BenitahInstitute for Research in Biomedicine, The Barcelona Institute of Science and Technology, Barcelona, Spain; Catalan Institution for Research and Advanced Studies, Barcelona, Spain.
Joseph S TakahashiDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Bogi AndersenCenter for Complex Biological Systems, University of California, Irvine, Irvine, California, USA; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California, USA; Division of Endocrinology, Department of Medicine, School of Medicine, University of California, Irvine, Irvine, California, USA. Electronic address: bogi@hs.uci.edu.

Funding

Control of hair follicle cyclingR01AR056439 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Bogi Andersen · 2010 to 2026
$5.4M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
Mentor Training to enhance mentorship in an interdisciplinary training programT32GM136624 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Arthur D Lander, Qing Nie · 2020 to 2026
$3.1M
Tissue Size and Precision Control in Growing Hair FolliclesR01AR079150 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Qing Nie, Maksim V Plikus · 2022 to 2026
$2.7M
Leveraging immune-fibroblast interactions for biomaterial induced skin regenerationR01AR079470 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCUMPIA, PHILIP · 2021 to 2025
$2.6M
NIAMS NIH HHS P30 AR075047NIAMS NIH HHS R01 AR056439NIAMS NIH HHS R01 AR079150NIAMS NIH HHS R01 AR079470NIGMS NIH HHS T32 GM136624
6 · The paper itself

Abstract

All skin layers and cutaneous appendages harbor a robust circadian clock, whose phase is under the influence of light through the central clock in the suprachiasmatic nucleus. The skin clock coordinates fundamental biological processes, including metabolism and stem cell activation. It also prominently modulates activity of skin-resident immune cells and the inflammatory response. Numerous diurnally regulated genes in the skin have been implicated in skin diseases in GWASs. Therefore, the mouse skin is a powerful model for understanding the diverse roles of circadian biology in maintaining tissue health and the initiation and propagation of disease states. When planning experiments to study the circadian biology of mouse skin, multiple technical and biological factors must be carefully considered. In this paper, we provide comprehensive guidance on the general circadian experimental design and associated housing for the mice. We highlight the importance of aligning sample collection with the desired hair cycle stage and animal age. We introduce methods to disrupt the clock in the skin, including altering light and feeding schedules as well as using transgenic mouse models. Finally, we discuss the use of transcriptomic data, both bulk and single cell, for circadian studies.

Indexed as

Circadian ClocksCircadian RhythmResearch DesignSkinAnimalsHumansMiceMice, TransgenicBioinformaticsCircadianSkinTransgenic mouse models

Identifiers

PMID39891645
PMCPMC13033321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.