Evidence map›Paper›PMID 39891456›Full record

ArticleArchives of Iranian medicine2024

Clinicopathologic Effects of Xenogeneic GvHD Induced by Adoptively Transferred Human-Derived T Cells in Severely Immunodeficient Mice.

Hami Ashraf, Farid Kosari, Amir Arsalan Khorsand, Samad Muhammadnejad, Vahid Mansouri, Ahad Muhammadnejad, Naser Ahmadbeigi, Seyed Mostafa Monzavi

Abstract read
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In one paragraph

Article in Archives of Iranian medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hami AshrafDigestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-1412-1773
Farid KosariDepartment of Pathology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Amir Arsalan KhorsandGene Therapy Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Samad MuhammadnejadINSERM U981, Institut Gustave Roussy, Villejuif, France.
Vahid MansouriGene Therapy Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Ahad MuhammadnejadCancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
Naser AhmadbeigiGene Therapy Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-7900-4546
Seyed Mostafa MonzaviGene Therapy Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-1631-1626

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundXenogeneic graft-versus-host disease (xGvHD) is an inevitable confounder of preclinical evaluation of adoptive immunotherapies on tumor-bearing immunodeficient mouse models. This study was designed to appraise the clinical and histopathological effects caused by xGvHD in severely immunodeficient mice considering the T cell dosage.

methodsFifty NOG mice underwent intraperitoneal injection of three different doses of human-derived total T cells, a high dose of CD8

resultsIn mice receiving higher doses of total T cells, the clinical severity of xGvHD was greater. However, recipients of CD8

conclusionIn preclinical evaluations, lower doses of T cell-based therapies are associated with milder xGvHD. Development of xGvHD may be averted by the use of CD4

Indexed as

Adoptive TransferCD8-Positive T-LymphocytesGraft vs Host DiseaseT-LymphocytesAnimalsDisease Models, AnimalFemaleHumansMiceMice, SCIDAdoptive immunotherapyEvaluationGraftHost diseaseImmunodeficient micePreclinical drugXenotransplantation

Identifiers

PMID39891456
PMCPMC11786209

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.