ArticleThe American journal of psychiatry2025
Real-Time Assessment of Alcohol Reward, Stimulation, and Negative Affect in Individuals With and Without Alcohol Use Disorder and Depressive Disorders.
Article in The American journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
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Who cites it
18 citing papers in PubMed.
- Across the spectrum: Acute alcohol responses in young adults with mild, moderate, and severe alcohol use disorder.Drug and alcohol dependence · 2025Trial
- Major depressive disorder-alcohol use disorder comorbidity: diagnosis, mechanisms and treatment.European archives of psychiatry and clinical neuroscience · 2026Review
- A Behavioral Economic Characterization of the Impact of the COVID-19 Quarantine on Reinforcer Diversity, Behavior, and Health.Perspectives on behavior science · 2026Review
- Modeling Concurrent Hedonic Disruption During Excessive Drinking and Abstinence-Related Negative Affect in a Novel Selectively Bred Mouse Line: The Crossed High Alcohol Preferring X High Drinking in the Dark (cHAPxHDID) Mice.Alcohol, clinical & experimental research · 2026Article
- Recent advances in individual differences in addiction neuroscience in animal models and clinical studies.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Revisiting the role of negative affect in alcohol use disorder: A longitudinal evaluation of Koob's allostatic model.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- Beyond Drug Reward: Heritable Sensitivity to Cocaine Aversion as a Determinant of Addiction Vulnerability.eNeuro · 2026Article
- The role of distress tolerance in the momentary relationship between negative affect and drinking in daily life.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- Psychiatric Comorbidities in Substance Use Disorders: Sex-Based Differences in a National Real-World Clinical Sample.The American journal of psychiatry · 2026Article
- Alcohol and Stress Together Can Lead to Long-Term, Dementia-Like Deleterious Effects in the Brain.Alcohol, clinical & experimental research · 2026Article
- Testing the robustness of daily associations of affect with alcohol and cannabis use.Journal of psychopathology and clinical science · 2026Article
- Argument for the pharmacokinetically-informed preclinical researcher: A commentary for Alcohol.Alcohol (Fayetteville, N.Y.) · 2026Article
- Using Mobile Technology to Study Episodes of Alcohol Self-Administration in Daily Life: A Narrative Review.Current addiction reports · 2026Review
- Taste matters: lessons learned in translating a conditioned drug cue reactivity paradigm from rodents to humans.Frontiers in psychology · 2026Article
- Latent profile analysis of trait impulsivity facets and associations with resilience, problematic alcohol use, and quality of life.Alcohol, clinical & experimental research · 2025Article
- Pace of alcohol drinking during in natural-environment drinking is associated with heightened alcohol-related reward and negative consequences in risky drinkers.Psychopharmacology · 2025Article
- A pilot study of impulsivity and subjective alcohol response in the lab and moment.Experimental and clinical psychopharmacology · 2025Article
- Stressed Avoider rats show blunted sensitivity to alcohol's aversive effects: Potential contributions of the lateral habenula and lateral hypothalamus.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveThe allostasis theory states that, as addiction develops, alcohol is consumed to relieve negative affect rather than to produce positive effects. This study aimed to investigate the real-time subjective effects of alcohol in individuals with alcohol use disorder (AUD) and those prone to negative affect by virtue of having comorbid depressive disorder (DEP).
methodsParticipants (N=221) completed high-resolution ecological momentary assessments during 3-hour monitoring of one alcohol drinking episode and one non-alcohol drinking episode in their natural environment. Participants also completed daily mood surveys and next-day surveys. Linear mixed-effect models were used to compare drinking behavior and subjective responses (stimulation, sedation, liking, wanting, negative affect) among 120 participants with AUD (AUD+; with depression [DEP+]: N=64, without depression [DEP-]: N=56) and 101 participants without AUD (AUD-; DEP+: N=45, DEP-: N=56).
resultsDuring the monitoring period, participants with AUD consumed an average of 8.5 standard alcohol drinks (estimated blood alcohol concentration [eBAC]=0.115 g/dl) versus 3.7 drinks (eBAC=0.040 g/dl) for non-AUD participants. The AUD group, regardless of comorbid DEP, reported increases in stimulation and rewarding effects that persisted throughout most of the alcohol episode relative to the non-alcohol episode. To a lesser extent, alcohol relieved negative affect but this was not specific to AUD or DEP groups.
conclusionsContrary to the allostasis model of addiction's emphasis on negative reinforcement drinking, findings demonstrated that people with AUD prone to negative affect displayed positive alcohol reinforcement with pronounced and prolonged sensitivity to alcohol's pleasurable effects, akin to their noncomorbid counterparts. The findings provided critical testing of addiction theories in the natural environment to enhance external validity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.