Evidence map›Paper›PMID 39891356›Full record

ArticleInternational journal of immunopathology and pharmacology

Circulating cell-free DNA as a potential biomarker for prediction of disease activity and prognosis among Egyptian rheumatoid arthritis patients.

Sara I Taha, Sara F Samaan, Sally Saber Hawash, Eman M El-Sehsah, Sara Shamloul, Dalia Hussein Helmy Elsheikh, Basim Othman, Mohammad A Albanghali, Saeedah H Aljadani, Abdalla Elmanna and 1 more

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Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Sara I TahaDepartment of Clinical Pathology, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.ORCID 0000-0001-8224-8701
Sara F SamaanDepartment of Internal Medicine, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Sally Saber HawashDepartment of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Eman M El-SehsahDepartment of Medical Microbiology and Immunology, Mansoura Faculty of Medicine, Mansoura, Egypt.
Sara ShamloulDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Dalia Hussein Helmy ElsheikhDepartment of Geriatrics medicine and Gerontology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID 0009-0003-6270-189X
Basim OthmanDepartment of Public Health, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia.
Mohammad A AlbanghaliDepartment of Public Health, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia.
Saeedah H AljadaniDepartment of Basic Sciences, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia.
Abdalla ElmannaDepartment of Public Health, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia.
Rasha Ahmed GhorabDepartment of Clinical Pathology, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell-free DNA (cfDNA) has emerged as a potential biomarker for assessing disease activity and prognosis in rheumatoid arthritis (RA). However, the association between cfDNA levels and the established RA markers of inflammation and disease severity remains unclear. The current study aimed to detect plasma levels of cfDNA in patients with RA and to investigate their association with RA activity indicators (erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), disease activity score-28 (DAS28)), prognostic markers (rheumatoid factor (RF), anticitrullinated protein antibodies (ACPA)), and the musculoskeletal ultrasonographic (US7) scores. This controlled cross-sectional study included 108 RA patients and 108 healthy controls. Plasma levels of cfDNA were quantified by real-time PCR using ALU repeats. Levels of ESR, CRP, RF, and ACPA were measured using routine laboratory assays. Synovial inflammation and joint damage evaluation was performed using the US7 scoring system. Plasma levels of cfDNA were higher in RA patients than controls (

Indexed as

Arthritis, RheumatoidCell-Free Nucleic AcidsAdultBiomarkersBlood SedimentationCase-Control StudiesC-Reactive ProteinCross-Sectional StudiesEgyptFemaleHumansMaleMiddle AgedPrognosisRheumatoid FactorSeverity of Illness IndexBiomarkersCell-Free Nucleic AcidsC-Reactive ProteinRheumatoid Factoractivitycell-free DNADAS28prognosisrheumatoid arthritisultrasound

Identifiers

PMID39891356
PMCPMC11786270

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