Evidence map›Paper›PMID 39891160›Full record

ArticleBMC musculoskeletal disorders2025

The Canadian Prospective Pragmatic Perilunate Outcomes (C3PO) trial; a protocol.

Eric C Mitchell, Isabelle Tottenham, Ruby Grewal, Matthew W T Curran, Neil J White

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04370626 (The Canadian Prospective Pragmatic Perilunate Outcomes Trial), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04370626 recruitingnot on this map

The Canadian Prospective Pragmatic Perilunate Outcomes Trial (The C3PO Trial)

Typeobservational_patient_registrySponsorUniversity of CalgaryRan2020 to 2026Enrolled450ConditionsWrist Injuries, Carpal Bone Fracture, Dislocation of Wrist, Trauma
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eric C MitchellDivision of Plastic Surgery, Western University, London, Canada.
Isabelle TottenhamCumming School of Medicine, University of Calgary, Calgary, Canada.
Ruby GrewalDivision of Orthopedic Surgery, Roth, cFMarlane Hand & Upper Limb Center, St Joseph's Health Care, London, Canada.
Matthew W T CurranDivision of Plastic Surgery, University of Alberta, Edmonton, Canada.
Neil J WhiteDivision of Orthopedic Surgery, University of Calgary, 4448 Front Street SE, Calgary, AB, T3M 1M4, Canada. neiljwhite@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerilunate spectrum injuries (PSI) are uncommon, but high-energy injuries that result in significant functional implications for patients. The existing literature on PSI is limited to small case-series and there are no evidence-based guidelines for management.

methodsThis manuscript outlines a protocol for a three-armed, national, multi-centre study, which includes a patient injury registry for PSI, as well as associated retrospective and prospective arms. The primary objective is to establish a national injury registry for patients who present with PSI. The secondary objectives are to examine the long-term clinical and radiographic outcomes of PSI, evaluate progression of these outcomes over time, and to examine the impact of specific operative and injury related factors on outcomes. DISCUSSION: This paper describes the protocol for a three-armed, multi-centre study of PSI. It outlines the rationale for the study as well as the relevant methodological details. An injury registry involving multiple centres is valuable given this is an uncommon injury with many potential variables affecting outcomes. Registry-based retrospective and prospective studies will benefit from the large clinical database provided by the registry and could be used to guide evidence-based treatment guidelines which are currently lacking in the literature.

trial registrationClinicaltrials.gov identifier: NCT04370626.

Indexed as

Lunate BoneWrist InjuriesCanadaHumansMulticenter Studies as TopicPragmatic Clinical Trials as TopicProspective StudiesRegistriesRetrospective StudiesTreatment OutcomeOperative treatmentPerilunate dislocationPerilunate fracture-dislocationWrist

Identifiers

PMID39891160
PMCPMC11783916

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.