ArticleBMC pediatrics2025
The study of pubertal stage and age of menarche in girls in Isfahan province, Iran.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Weight status is associated with puberty timing in girls in Isfahan province, Iran.BMJ paediatrics open · 2026Article
- Secular trends in menarche age among Iranian girls: Probit analysis on cross-sectional data of Persian (Shahedieh) cohort.International journal of reproductive biomedicine · 2026Article
- Associations of Urinary Metabolites of Parabens and Bisphenol a with Premature Thelarche among a Sample of Iranian GirlsJournal of clinical research in pediatric endocrinology · 2026Article
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6 authors.
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Abstract
backgroundThe onset age of pubertal changes varies widely among girls and has undergone changes over time around the world. This study aimed to determine the age of onset of puberty in healthy Iranian girls living in Isfahan province.
methodsThis cross- sectional study was conducted among 13,886 students aged 6-18 years. They were selected by multistage random cluster sampling from urban and rural areas of Isfahan province of Iran. Pubertal stage was determined according the 5-level Tanner stages proposed by Marshall and Tanner. Trained physicians determined the breast development through both visual inspection and palpation, in addition, mothers assessed their daughter's pubic hair growth using Tanner's Sexual Maturation Scale (SMS) by comparison to standard pictures. The data were analyzed by the status quo method. Probit regression analysis was used to evaluate the median age of onset for each characteristic including menarche, breast and pubic hair.
resultsA total of 13,886 healthy girls with mean age (SD) of 11.97 (2.9) were studied. Overall 6968 (50.2%) girls experienced menstruation with a median (95%CI) age of 12.05(11.88-12.21) years at its onset. The median age for onset of breast development was 9.89 (95% CI: 9.77 - 10.02) years and for onset of pubic hair development was 10.14 (95% CI: 9.88- 10.39) years. The 3rd percentile for breast stage 2 (B2) and pubic hair stage 2 (PH2) was 6.85 and 6.75 years, respectively, and the 97th percentile for B2 and PH2 was 12.94and 13.54 years, respectively.
conclusionAccording to our findings, the onset of puberty before 6.85 years should be considered as precocious puberty for Iranian girls. Our study indicated the secular trend toward earlier menarche in girls. Nationally representative surveys and longitudinal studies are necessary to determine the exact age of puberty for future international comparisons.
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