ArticleBMC cancer2025
Intravoxel incoherent motion (IVIM) MRI-derived masseter muscle characteristics: a new diagnostic marker in head and neck cancer?
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The Deep Head of the Masseter Muscle: A Classification-Based Anatomical and Surgical Framework.Biomedicines · 2025Review
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Authors and funding
8 authors.
Funding
Abstract
backgroundTo use intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) to evaluate the masseter muscle and tumors in patients with head and neck cancer (HNC) and to compare them with those of normal controls.
methodsThe study involved 16 normal controls and 54 patients with HNC (29 newly diagnosed and 25 posttreatment cases) examined using a 3.0T MRI with a 20-channel head and neck coil. IVIM scans, incorporating six b-values in three orthogonal directions, were conducted using a readout-segmented echo-planar sequence. The diffusion coefficient (D), perfusion fraction (f), and pseudodiffusion coefficient (D*) were derived to assess the diffusion and perfusion alterations in the masseter muscles and HNC lesions.
resultsThe masseter muscle f values significantly differed between the patients with newly diagnosed HNC and the normal controls (p < 0.05); no significant differences in remaining D, D*, and f values were observed between the three groups (p > 0.05). The masseter muscle volumes in the newly diagnosed HNC and posttreatment patients were significantly smaller than those in the normal controls (all p < 0.05). The D and f values of the bilateral masseter muscles in the patients with newly diagnosed HNC were significantly higher than those in the primary cancer lesions (p < 0.05).
conclusionsOur study highlights the potential of IVIM parameters for the evaluation of masseter muscles in patients with HNC, with elevated f values on the ipsilateral side of primary tumors and bilaterally increased D and f values. The clinical implications and underlying mechanisms of these findings of distinct perfusion changes warrant further exploration.
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