ArticleBMC microbiology2025
Optimization and characterization of bioactive secondary metabolites from Streptomyces sp CMSTAAHL-4 isolated from mangrove sediment.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Evaluation of Antibacterial Properties of Nanosuspension of Secondary Metabolites from Streptomyces chrestomyceticus ADP4.Current microbiology · 2026Article
- Integrated GC-MS and UHPLC-HRMS/MS profiling of bioactive compounds from Streptomyces sp. BPA-6 isolated from bees-collected pollen.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Mangrove soil-derived Streptomyces viridiostaticus as a source of dual therapeutic bioactives: antimicrobial proteins and Tryprostatin B alkaloid with anticancer potency.Molecular biology reports · 2026Article
- Genome-guided discovery and computational prioritization of next generation drug development fromFrontiers in microbiology · 2026Article
- Genomic exploration andFrontiers in bioinformatics · 2026Article
- Screening the Antibiotic Activity of Cave Actinobacteria Against Multidrug-Resistant Strains ofInternational journal of microbiology · 2026Article
- Bioactive compounds from marine algae in pancreatic cancer therapy: mechanistic insights into fucoidan and phlorotannins: a review.Medical oncology (Northwood, London, England) · 2025Review
- Optimization and Characterization of Bioactive Metabolites from Cave-DerivedBiomolecules · 2025Article
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Authors and funding
6 authors.
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Abstract
backgroundTen morphologically different actinomycetes were isolated from mangrove sediments of Manakudy, Kanyakumari District, India. The potent strain was selected based on their primary screening against Gram positive Staphylococcus aureus, Enterococcus faecalis and Gram negative Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi bacterial pathogens. The selected strain was identified as Streptomyces sp CMSTAAHL-4 by 16S rRNA sequencing. The media optimization for secondary metabolites production was performed by One-Variable at a Time and Response Surface Methodology-Central Composite Design. Minimum inhibitory concentration and minimum bacterial concentration for the extracted secondary metabolites were determined. The antioxidant potential of the secondary metabolites showed that the concentration of the metabolites increases, with the percentage of inhibition. The anti-inflammatory activity of the secondary metabolites found that maximum activity was observed at 500 µg/ml of the metabolites. Alcohols, alkenes, alkynes, alkyl halides, carboxylic acids, aliphatic esters functional groups were identified by fourier transform infrared spectroscopy, gas chromatography and mass spectrometer analysis of the secondary metabolites revealed five bioactive compounds. The X-ray diffraction analysis revealed that the secondary metabolites are amorphous. The thermogravimetric analysis showed the thermal stability of secondary metabolites. Atomic force microscopy analysis revealed specific structural characteristics of the secondary metabolites, which may be associated with their potential biological activities.
conclusionsThe results showed that the antibacterial, antioxidant, and anti-inflammatory chemicals present in the isolated secondary metabolites give them therapeutic properties.
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