ArticleNature immunology2025
Progressively differentiated T
Abstract read
In one paragraph
Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Regulation of follicular helper T cell subset differentiation in health and disease.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Interleukin-4-producing type 2 innate lymphoid cells in the lymph node promote proallergic Tfh13 cell differentiation.Immunity · 2026Article
- Multiple roads to IgE memory: A pluralistic model of IgE immunity.Cell reports · 2026Review
- Stability and progressive differentiation of TNature immunology · 2026Article
- Cross-species transcriptomic evidence for peripheral-central immune crosstalk in atopic dermatitis.Frontiers in immunology · 2026Article
- Type 2 Inflammatory Diseases: The Crossroads of Immunity and Metabolism.Research (Washington, D.C.) · 2026Review
- Using Biologics in the Prevention of Anaphylaxis.Current allergy and asthma reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Pragya ChandrakarTransplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Cody S NelsonTransplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1046-455X
Manuel A PodestàTransplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6684-2524
Cecilia B CavazzoniTransplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Maya GemplerTransplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jeong-Mi LeeTransplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sierra RichardsonTransplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Hengcheng ZhangTransplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2562-1247
Snigdha SamarpitaTransplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Maria CiofaniDepartment of Integrative Immunology, Duke University Medical Center, Durham, NC, USA.ORCID http://orcid.org/0000-0001-6472-5260
Talal ChatilaDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7439-2762
Vijay K KuchrooGene Lay Institute of Immunology and Inflammatory Diseases, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7177-2110
Peter T SageTransplantation Research Center, Division of Renal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. psage@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-7287-0326
Funding
Transgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BLAZAR, BRUCE R · 2003 to 2023
$42.5MIMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITYT32AI007306 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Nora Amanda Barrett, Joshua A Boyce · 1985 to 2026
$12.2MMolecular Basis of Hyper lgE ImmunodeficiencyR01AI065617 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Talal Amine Chatila · 2006 to 2026
$10.9MEffect of IL-4RαR576 variant on response to Dupilumab in children with AsthmaU01AI143514 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHATILA, TALAL AMINE, PHIPATANAKUL, WANDA · 2019 to 2023
$8.4MMedical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6MImmunological and Microbial Mechanisms in Food AllergyR01AI126915 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Talal Amine Chatila, Seth Rakoff-Nahoum · 2017 to 2026
$4.9MThe role of AP-1 family transcription factor networks in regulating TH17 cell effector identityR01GM115474 · NIGMS · DUKE UNIVERSITY · PI CIOFANI, MARIA · 2016 to 2024
$3.2MHumoral Immunoregulation of Allergic Disease by Follicular T Cell SubsetsR01AI153124 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter The Sage · 2021 to 2026
$3.2MTargeting microbial dysbiosis in Food Allergy to restore toleranceR01AI158814 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHATILA, TALAL AMINE, RAKOFF-NAHOUM, SETH · 2021 to 2025
$3.0MNovel NOTCH4 Pathway of Asthma Severity in Urban School Children: Clinical Research Center, Boston Children’s HospitalU01AI160087 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Talal Amine Chatila, WANDA PHIPATANAKUL · 2021 to 2026
$2.8MMetabolic regulators of Treg/Th17 balance in CNS autoimmunityR01AI169075 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI VIJAY K. KUCHROO · 2022 to 2026
$2.8MControl of Humoral and Cellular Immunity to Viral Infections of the Lung by Follicular CD8 T CellsR01AI158413 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SAGE, PETER THE · 2021 to 2025
$2.5MNCI NIH HHS R01 CA282794NIAID NIH HHS P01 AI056299NIAID NIH HHS R01 AI065617NIAID NIH HHS R01 AI126915NIAID NIH HHS R01 AI153124NIAID NIH HHS R01 AI158413NIAID NIH HHS R01 AI158814NIAID NIH HHS R01 AI169075NIAID NIH HHS T32 AI007306NIAID NIH HHS U01 AI143514NIAID NIH HHS U01 AI160087NIGMS NIH HHS R01 GM115474NIGMS NIH HHS T32 GM145449U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM115474U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) P01AI056299U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI065617U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI158413U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32AI007306
Abstract
Allergic diseases are common and affect a large proportion of the population. Interleukin-13 (IL-13)-expressing follicular helper T (T
Indexed as
AllergensGerminal CenterHypersensitivityT Follicular Helper CellsT-Lymphocytes, Helper-InducerTranscription FactorsAnimalsB-LymphocytesCell DifferentiationImmunoglobulin EImmunoglobulin GInterleukin-13Interleukin-21InterleukinsMiceMice, Inbred C57BLAllergensImmunoglobulin EImmunoglobulin GInterleukin-13Interleukin-21InterleukinsJunB protein, mouseTranscription Factors
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.