Evidence map›Paper›PMID 39890974›Full record

ArticleScientific reports2025

Temperature and repeated catecholamine surges modulate regional wall motion abnormalities in a rodent takotsubo syndrome model.

Ermir Zulfaj, AmirAli Nejat, Abdulhussain Haamid, Aaron Espinosa, Ahmed Elmahdy, Tetiana Pylova, Sandeep Jha, Björn Redfors, Elmir Omerovic

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ermir ZulfajDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at Gothenburg University, Bruna Stråket 16, Gothenburg, 413 45, Sweden. ermir.zulfaj@gu.se.
AmirAli NejatDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at Gothenburg University, Bruna Stråket 16, Gothenburg, 413 45, Sweden.
Abdulhussain HaamidCore Facilities - Experimental Biomedicine, Sahlgrenska Academy, Göteborg, Sweden.
Aaron EspinosaDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at Gothenburg University, Bruna Stråket 16, Gothenburg, 413 45, Sweden.
Ahmed ElmahdyDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at Gothenburg University, Bruna Stråket 16, Gothenburg, 413 45, Sweden.
Tetiana PylovaDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at Gothenburg University, Bruna Stråket 16, Gothenburg, 413 45, Sweden.
Sandeep JhaDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at Gothenburg University, Bruna Stråket 16, Gothenburg, 413 45, Sweden.
Björn RedforsDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at Gothenburg University, Bruna Stråket 16, Gothenburg, 413 45, Sweden.
Elmir OmerovicDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at Gothenburg University, Bruna Stråket 16, Gothenburg, 413 45, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient regional wall motion abnormalities (RWMA) after stress are a hallmark of experimental and clinical Takotsubo Syndrome (TS). The mechanisms driving RWMA remain incompletely understood. This study investigates these mechanisms in a small-animal model of TS, validating the model's complication profile, recovery dynamics, and recurrence, while assessing the predictive value of echocardiography. Male, 7-9-week-old rats underwent TS induction via isoprenaline infusion. The effects of body temperature and repeated catecholaminergic surges on RWMA were assessed using high-resolution speckle-tracking echocardiography. Complications were evaluated through ECG, autopsy, and blood gas analysis. The TS phenotype showed reduced longitudinal strain with RWMA characterized by apical end-systolic akinesia/dyskinesia, a contracting base, and a narrow transition zone, resulting in apical ballooning. RWMA originated from the apex and recovered in the opposite direction. Hyperthermia increased RWMA incidence, while hypothermia attenuated RWMA (p = 0.008). A repeated catecholamine surge exacerbated RWMA in the acute phase (p = 0.042) but not during recovery (p = 0.308), with reduced RWMA susceptibility after recovery (RR 0.45, 95%CI; 0.27-0.76). Systolic function at initial echocardiography predicted worse outcomes (odds ratio 0.73; 95%CI 0.57-0.85), and RWMA extent correlated with recovery time (Rho = 0.772). TS rats developed complications similar to patients, including heart failure, arrhythmias, and thrombus formation. This study validates the small-animal TS model by replicating patient findings, and emphasizing the importance of controlling body temperature and limiting adrenergic drug use in managing TS. RWMA analysis offers promise as a diagnostic and prognostic tool in TS, and the delayed adaptive response presents a potential pathway for therapeutic intervention.

Indexed as

Body TemperatureCatecholaminesTakotsubo CardiomyopathyAnimalsDisease Models, AnimalEchocardiographyIsoproterenolMaleRatsRats, Sprague-DawleyCatecholaminesIsoproterenolBody temperatureCatecholamineComplicationEchocardiographyRat modelRegional Wall Motion abnormalitiesTakotsubo Syndrome

Identifiers

PMID39890974
PMCPMC11785725

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.