Evidence map›Paper›PMID 39890920›Full record

ArticleMolecular psychiatry2025

Dopaminergic deficits along the spectrum of Alzheimer's disease.

Andrea Pilotto, Alice Galli, Arianna Sala, Silvia Paola Caminiti, Luca Presotto, Claudio Liguori, Nicola Biagio Mercuri, Enrico Premi, Valentina Garibotto, Giovanni Frisoni and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Dopamine System Dysfunction in Alzheimer's Disease.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2025
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Andrea Pilotto *Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy. pilottoandreae@gmail.com.ORCID 0000-0003-2029-6606
Alice Galli *Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy.
Arianna SalaComa Science group- University of Liege, Liège, Belgium.
Silvia Paola CaminitiDepartment of Brain and Behavioral Sciences- Univeristy of Pavia, Pavia, Italy.
Luca PresottoDepartment of Physics "G. Occhialini", University of Milano-Bicocca, Milan, Italy.
Claudio LiguoriNeurophysiology Unit, Sleep and Epilepsy Center- University of Rome Tor Vergata, Rome, Italy.
Nicola Biagio MercuriNeurophysiology Unit, Sleep and Epilepsy Center- University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0001-6700-7491
Enrico PremiStroke Unit, ASST Spedali Civili Brescia Hospital, Brescia, Italy.ORCID 0000-0002-4342-6963
Valentina GaribottoDepartment of Radiology and Medical Informatics- Geneva University Hospital, Geneva, Switzerland.ORCID 0000-0003-2422-698X
Giovanni FrisoniDepartment of Psychiatry- Geneva University Hospital, Geneva, Switzerland.
Agostino ChiaravallotiDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Orazio SchillaciDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Marcello D'AmelioDepartment of Experimental Neurosciences, IRCCS Santa Lucia Foundation, Rome, Italy.ORCID 0000-0001-6526-1832
Barbara PagheraNuclear Medicine Unit- University of Brescia, Brescia, Italy.
Silvia LucchiniNuclear Medicine Unit- University of Brescia, Brescia, Italy.
Francesco BertagnaNuclear Medicine Unit- University of Brescia, Brescia, Italy.
Daniela PeraniUniversity Vita-Salute San Raffaele, IRCCS San Raffaele Hospital, Milan, Italy.
Alessandro PadovaniDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy.ORCID 0000-0002-0119-3639

Funding

Ministero della Salute (Ministry of Health, Italy) RF-2018-12366209Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) MNESYS project (DN.1553)Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) #NEXTGENERATIONEU
6 · The paper itself

Abstract

Both post-mortem and in vivo data argue for dopamine dysfunction in patients with Alzheimer's Disease (AD). However, the timing and regional progression of dopaminergic systems alterations in AD are still debated. The aim of the study was to investigate in vivo the pattern of dopaminergic changes and connectivity using DAT-SPECT imaging in patients across the AD spectrum. Fifty-nine AD patients (n = 21 AD-MCI; n = 38 AD-DEM) and a control group (CG) of n = 45 age- and sex-matched individuals entered the study and underwent

Indexed as

Alzheimer DiseaseDopamineAgedAged, 80 and overBrainCognitive DysfunctionDopamine Plasma Membrane Transport ProteinsFemaleHumansMaleMiddle AgedNeural PathwaysTomography, Emission-Computed, Single-PhotonTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropaneDopamineDopamine Plasma Membrane Transport ProteinsTropanes

Identifiers

PMID39890920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.