Evidence map›Paper›PMID 39890871›Full record

ArticleScientific reports2025

TRα1 mutant suppresses KLF9 to cause endometrial metaplasia with ectopic IL-33 expression leading to uterine fibrosis and infertility.

Elijah Edmondson, Takahito Kimura, Eunmi Hwang, Minjun Kim, Andrew Warner, Yuelin Zhu, Li Zhao, Yanlin Yu, Xuguang Zhu, Maria Hernandez and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elijah EdmondsonFrederick National Laboratory for Cancer Research, Frederick, MD, USA.
Takahito KimuraNational Cancer Institute, National Institutes of Health, Bethesda, USA.
Eunmi HwangNational Cancer Institute, National Institutes of Health, Bethesda, USA.
Minjun KimNational Cancer Institute, National Institutes of Health, Bethesda, USA.
Andrew WarnerFrederick National Laboratory for Cancer Research, Frederick, MD, USA.
Yuelin ZhuNational Cancer Institute, National Institutes of Health, Bethesda, USA.
Li ZhaoNational Cancer Institute, National Institutes of Health, Bethesda, USA.
Yanlin YuNational Cancer Institute, National Institutes of Health, Bethesda, USA.
Xuguang ZhuNational Cancer Institute, National Institutes of Health, Bethesda, USA.
Maria HernandezNational Cancer Institute, National Institutes of Health, Bethesda, USA.
Noemi KedeiNational Cancer Institute, National Institutes of Health, Bethesda, USA.
Sheue-Yann ChengNational Cancer Institute, National Institutes of Health, Bethesda, USA. chengs@mail.nih.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid hormone receptors (TRs) mediate the genomic actions of thyroid hormone. Mutations of THRA gene cause a human disease known as resistance to thyroid hormone (RTHα). We created a mouse model expressing a dominant negative mutated TRα1 (Thra1

Indexed as

EndometriumInfertility, FemaleInterleukin-33Kruppel-Like Transcription FactorsAnimalsDisease Models, AnimalFemaleFibrosisMetaplasiaMiceMutationUterusIl33 protein, mouseInterleukin-33Klf9 protein, mouseKruppel-Like Transcription FactorsEndometrial metaplasiaFemale reproductionInfertilityKLF9Resistance to thyroid hormoneSpatial transcriptomicsThyroid hormone receptor α1

Identifiers

PMID39890871
PMCPMC11785771

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.