Evidence map›Paper›PMID 39890704›Full record

ArticleCell biochemistry and biophysics2025

Ophiopogonin D Alleviates Sepsis-Induced Acute Lung Injury Through Improving Microvascular Endothelial Barrier Dysfunction via Inhibition of HIF-1α-VEGF Pathway.

Yi Fang, Jun Qiu, Yu Xu, Qing Wu, Xing-Chen Huo, Song-Hua Liu

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Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi FangDepartment of Anesthesiology, Affiliated Changsha Central Hospital to Nanhua University, Changsha, 410016, Hunan, PR China.
Jun QiuThe first-affiliated hospital of Hunan normal university (The second tumor ward, Hunan Provincial People's Hospital), Changsha, 410006, Hunan, PR China.
Yu XuDepartment of Anesthesiology, Affiliated Changsha Central Hospital to Nanhua University, Changsha, 410016, Hunan, PR China.
Qing WuDepartment of Anesthesiology, Affiliated Changsha Central Hospital to Nanhua University, Changsha, 410016, Hunan, PR China.
Xing-Chen HuoDepartment of Anesthesiology, Affiliated Changsha Central Hospital to Nanhua University, Changsha, 410016, Hunan, PR China.
Song-Hua LiuDepartment of Anesthesiology, Affiliated Changsha Central Hospital to Nanhua University, Changsha, 410016, Hunan, PR China. liusonghua3150@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary endothelial barrier dysfunction is a hallmark of sepsis-induced acute lung injury (ALI). Ophiopogonin D (OP-D), isolated from the roots of Ophiopogon japonicus, is involved in regulating inflammation, apoptosis and intestinal permeability. However, the role of OP-D in ALI has not been reported and the related mechanisms remain unclear. In this study, cecal ligation and puncture (CLP) was used to establish a septic ALI model in mice. We found that OP-D effectively alleviated lung pathological damage. Moreover, OP-D decreased pulmonary microvascular permeability, restrained the inflammatory response and apoptosis in murine lung tissues and LPS-exposed PMVECs. Specifically, OP-D exerted the beneficial effects via mediating the inactivation of HIF-1α-VEGF pathway, which was partly abrogated by the overexpression of HIF-1α. Collectively, our findings showed that OP-D protected against sepsis-induced ALI through improving pulmonary microvascular endothelial barrier dysfunction via suppressing HIF-1α-VEGF pathway.

Indexed as

Acute Lung InjuryHypoxia-Inducible Factor 1, alpha SubunitSaponinsSepsisSignal TransductionSpirostansVascular Endothelial Growth Factor AAnimalsApoptosisCapillary PermeabilityEndothelial CellsLipopolysaccharidesLungMaleMiceMice, Inbred C57BLHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitLipopolysaccharidesophiopogonin DSaponinsSpirostansVascular Endothelial Growth Factor AHIF-1α-VEGF pathwayMicrovascular endothelial barrier dysfunctionOphiopogonin DSeptic acute lung injury

Identifiers

PMID39890704

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.