Evidence map›Paper›PMID 39890685›Full record

ArticleJournal of molecular neuroscience : MN2025

Analysis of Common Genetic Variation of Anxiety Disorders in Essential Tremor.

Yaping Yan, Lanxiao Cao, Luyan Gu, Congying Xu, Jinyu Lu, Dayao Lv, Jun Tian, Xinzhen Yin, Jiali Pu, Baorong Zhang and 1 more

Abstract read
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In one paragraph

Article in Journal of molecular neuroscience : MN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yaping Yan *Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
Lanxiao Cao *Department of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, N1 Shangcheng Avenue, Yiwu, 322000, Zhejiang, China.
Luyan GuDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
Congying XuDepartment of Neurology, Jiaxing Second Hospital, Jiaxing, China.
Jinyu LuDepartment of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, N1 Shangcheng Avenue, Yiwu, 322000, Zhejiang, China.
Dayao LvDepartment of Neurology, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, N1 Shangcheng Avenue, Yiwu, 322000, Zhejiang, China.
Jun TianDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
Xinzhen YinDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
Jiali PuDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
Baorong ZhangDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China. brzhang@zju.edu.cn.
Guohua ZhaoDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China. gzhao@zju.edu.cn.

Funding

Major Health Science and Technology Program of Zhejiang Province WKJ-ZJ-2208Medical and Health Research Project of Zhejiang Province 2021RC065the Key Projects of Zhejiang Provincial Natural Science Fund LZ23H090004
6 · The paper itself

Abstract

The objective of this study is to explore the association of common genetic variation of anxiety disorders and essential tremor (ET). We genotyped 25 anxiety-specific risk variants in a cohort of 478 unrelated ET patients and 504 age and gender-matched healthy controls from eastern China using a MassARRAY system. The association between candidate variants and ET patients was evaluated using gene-based analysis. A total of 159 patients (33.3%) had anxiety. In genotypic analysis, rs708012 (in an intergenic region) in the dominant models was found to be significantly associated with ET (P < 0.001, OR = 0.605). In allelic analysis, the carriers of the C allele of NTRK2 rs1187280 (P = 0.027, OR = 0.626), T allele of TMEM106B rs3807866 (P = 0.030, OR = 1.287), and T allele of rs708012 (P < 0.001, OR = 0.679) occupy a larger proportion of ET patients compared with healthy controls. Anxiety-specific risk SNPs of TMEM106B rs3807866 increase the risk for ET, while two SNPs of NTRK2 rs1187280 and rs708012 show a protective role.

Indexed as

Anxiety DisordersEssential TremorMembrane ProteinsNerve Tissue ProteinsPolymorphism, Single NucleotideReceptor, trkBAgedFemaleHumansMaleMembrane GlycoproteinsMiddle AgedMembrane GlycoproteinsMembrane ProteinsNerve Tissue ProteinsReceptor, trkBTMEM106B protein, humantropomyosin-related kinase-B, humanAnxietyEssential tremorGeneticVariant

Identifiers

PMID39890685

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.