Highly stable SERS-based mirrored aptasensor for selective detection of alpha-fetoprotein.

Xuning Kang, Zhongmei Peng, Qiulan Li, Zhenlin Fan, Jingping Zhang, Yuzhu Song, Jinyang Zhang, Qinqin Han

Abstract read

In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xuning Kang *Engineering Research Center for Molecular Diagnosis, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.

Zhongmei Peng *Engineering Research Center for Molecular Diagnosis, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.

Qiulan LiEngineering Research Center for Molecular Diagnosis, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.

Zhenlin FanEngineering Research Center for Molecular Diagnosis, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.

Jingping ZhangEngineering Research Center for Molecular Diagnosis, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.

Yuzhu SongEngineering Research Center for Molecular Diagnosis, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.

Jinyang ZhangEngineering Research Center for Molecular Diagnosis, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.

Qinqin HanEngineering Research Center for Molecular Diagnosis, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China. qqhan10@kust.edu.cn.

Funding

National Natural Science Foundation of China 32160601

6 · The paper itself

Abstract

An aptasensor was developed based on surface-enhanced Raman spectroscopy (SERS) to detect alpha-fetoprotein (AFP) using a mirror aptamer. AFP triggered and altered SERS signaling molecules through the release recognition mechanism as they are released. Two signaling molecules, cyanine 3 (Cy3) and 2-mercaptobenzimidazole-5-carboxylic acid (MBIA), were used to quantify AFP. The results showed that AFP could be reliably and sensitively detected in the concentration range 0.0038-100 ng/mL (R

Indexed as

alpha-FetoproteinsAptamers, NucleotideBiosensing TechniquesSpectrum Analysis, RamanBenzimidazolesCarbocyaninesGoldHumansLimit of DetectionMetal Nanoparticlesalpha-FetoproteinsAptamers, NucleotideBenzimidazolesCarbocyaninescyanine dye 3GoldAFPAptamerAptasensorSurface-enhanced Raman spectroscopy

Identifiers

PMID39890683

DOI10.1007/s00604-025-06985-6

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.