ArticleInternational ophthalmology2025
A comparison of endothelial cell count, central corneal thickness and intraocular pressure in different ethnic groups in the Western Cape, South Africa.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo compare endothelial cell counts (ECC), central corneal thickness (CCT) and intraocular pressure (IOP) in different ethnic groups.
methodsBetween January 2019 and December 2021, we enrolled 373 patients who self-identified as native African (116), ethnically diverse (157) or of European descent (100). Mean intraocular pressure (IOP), CCT and ECC were recorded.
resultsIOP was similar between the groups (African mean IOP 15.7 ± 2.2 mmHg, ethnically diverse 15.8 ± 2.2 mmHg, European 16.0 ± 2.0 mmHg, p = 0.48). There were age differences but no gender differences between ethnic groups. Mean CCT was 503.6 ± 30.0 µm (African), 516.8 ± 30.0 µm (ethnically diverse) and 539.1 ± 34.2 µm (European) (p < 0.002 for all). Mean ECC was 2775 ± 272 cells/mm
conclusionECC was highest in Africans with lowest CCT and conversely, Europeans demonstrated lowest ECC and highest CCT. Ethnically diverse participants demonstrated values between those of Africans and Europeans. We hypothesize that genomic research is required to determine if these differences have a genetic basis.
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