Evidence map›Paper›PMID 39890668›Full record

ArticleMikrochimica acta2025

Bioinspired rational spatial-arrangement of antigens enables the accurate and rapid detection of anti-p53 autoantibody.

Qiwen Liu, Jianfen Su, Jiamei Chen, Shuo Yang, Yang Huang, Rentao Tang, Zhengjin Jiang, Shengfeng Huang

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiwen Liu *Guangzhou Municipal and Guangdong Provincial KeyLaboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China.
Jianfen Su *The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, 510000, China.
Jiamei ChenGuangzhou Municipal and Guangdong Provincial KeyLaboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China.
Shuo YangGuangzhou Municipal and Guangdong Provincial KeyLaboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China.
Yang HuangGuangzhou Municipal and Guangdong Provincial KeyLaboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China.
Rentao TangGuangzhou Municipal and Guangdong Provincial KeyLaboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China.
Zhengjin JiangInstitute of Pharmaceutical Analysis, College of Pharmacy/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou, 510632, China. jzjjackson@hotmail.com.
Shengfeng HuangGuangzhou Municipal and Guangdong Provincial KeyLaboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China. hsf@gzhmu.edu.cn.

Funding

Guangdong Basic and Applied Basic Research Foundation 2022A1515110641National Natural Science Foundation of China 82304444
6 · The paper itself

Abstract

A highly sensitive antibody detection strategy is presented that leverages the rational spatial arrangement of antigens at the sensing interface. Specifically, we employed rigid benzene ring-based coupling agents, carefully controlling their density and orientation on the biosensing interface to establish a well-defined spatial arrangement of receptor molecules, thereby enhancing antibody binding efficiency. Additionally, we utilized Au-decorated MoS

Indexed as

AntigensAutoantibodiesBiosensing TechniquesTumor Suppressor Protein p53DisulfidesElectrochemical TechniquesElectrodesGoldHumansImmunoassayLimit of DetectionMolybdenumAntigensAutoantibodiesDisulfidesGoldMolybdenummolybdenum disulfideTumor Suppressor Protein p53Anti-p53 autoantibodyAutoantibody detectionBiosensorsElectrochemical impedance biosensor

Identifiers

PMID39890668

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.