Evidence map›Paper›PMID 39890665›Full record

ArticleNeuromolecular medicine2025

Time of the Day of Traumatic Brain Injury has Minimal Effects on Behavioral and Histological Outcomes in Mice of Both Sexes.

Charles K Davis, Soomin Jeong, Shruti Subramanian, Jeongwoo Choi, Carlie M Ostrom, Sena Park, Raghu Vemuganti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuromolecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Charles K DavisDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Ave, Madison, WI, USA.
Soomin JeongDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Ave, Madison, WI, USA.
Shruti SubramanianDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Ave, Madison, WI, USA.
Jeongwoo ChoiDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Ave, Madison, WI, USA.
Carlie M OstromDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Ave, Madison, WI, USA.
Sena ParkDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Ave, Madison, WI, USA.
Raghu VemugantiDepartment of Neurological Surgery, University of Wisconsin, 600 Highland Ave, Madison, WI, USA. vemuganti@neurosurgery.wisc.edu.

Funding

Role of RNAs in post-stroke brain damageR35NS132184 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Raghu VEMUGANTI · 2023 to 2026
$4.1M
BLRD VA I01 BX004344BLRD VA I01 BX005127BLRD VA IK6 BX005690NIH HHS R35NS132184NINDS NIH HHS R35 NS132184U.S. Department of Veterans Affairs I01BX004344
6 · The paper itself

Abstract

Transcription of > 50% of the mammalian coding genes follows circadian rhythm in an organ-specific manner. Recent findings highlighted the influence of time of the day in the progression of various neurological diseases and therapies. In the present study, we evaluated the effect of time of occurrence of traumatic brain injury (TBI) on behavioral and neuropathological outcomes in mice of both sexes. Following a controlled cortical impact injury induced between Zeitgeber time (ZT)1-4 or ZT13-16, behavioral deficits and brain damage were evaluated. There were no significant differences in post-TBI motor function between groups ZT1-4 and ZT13-16 in either male or female mice compared with the sex-matched naïve control. TBI-induced anxiety-like behavior was significantly higher in the female ZT13-16 cohort compared to the naïve cohort; but, no difference was observed between injured groups in both sexes. Similarly, spatial learning and memory were not significantly different between the ZT1-4 and ZT13-16 groups in both sexes. Post-TBI cortical lesion volume was also not significantly different between ZT1-4 and ZT-13-16 groups in both sexes. The present study observed no significant effects of occurrence time on TBI-induced brain damage or behavioral deficits in male and female mice.

Indexed as

Behavior, AnimalBrain Injuries, TraumaticCircadian RhythmAnimalsAnxietyCerebral CortexFemaleMaleMaze LearningMiceMice, Inbred C57BLMotor ActivitySex FactorsSpatial LearningTime FactorsAnxiety-like behaviorBrain injuryCognitionDiurnal cycleMotor function

Identifiers

PMID39890665
PMCPMC12013654

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.