Observational studyClinical oral investigations2025
An observational study of alveolar-derived autologous blood clot used in regenerative endodontic treatment for immature permanent teeth with pulp necrosis.
Observational study in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Regenerative endodontic treatment for premolars with apical root segment separation and extensive periapical lesions secondary to severe inflammatory root resorption: A report of two cases.Experimental and therapeutic medicine · 2026Article
- Alveolar-derived autologous blood clot as a scaffold for regenerative endodontic treatment: An observational study.Bioinformation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study introduces the alveolar-derived autologous blood (ADAB) clot, obtained by maxillary alveolar bone puncture, as a novel scaffold for regenerative endodontic treatment (RET). The purpose of this study is to verify the feasibility of using ADAB clots in RET by evaluating their cellular content, postoperative pain intensity, and clinical outcomes in the management of immature permanent teeth with pulp necrosis. MATERIALS AND
methodsBlood routine examinations were performed to analyze the cell content of peripheral venous blood (PVB) and ADAB. Postoperative pain intensity scores were recorded using the Numerical Rating Scale (NRS) at four time points: upon complete recovery from anesthesia, and at 12, 24, and 48 h postoperatively. Five immature premolars with pulp necrosis were treated by RET with ADAB clots. Radiographic root area (RRA) was analyzed using ImageJ software on oral radiographs obtained immediately after treatment and at the final follow-up (6-18 months).
resultsThe percentage difference in cell types between two groups (n = 8 per group) were not significant, except for blood platelets (PLT). The PLT count in the ADAB group (133.38 ± 119.62) was approximately half that of the PVB group (268.88 ± 52.82). Postoperative pain (n = 9) was predominantly mild upon anesthesia recovery and at 12 h postoperatively, while the majority of participants reported no pain at 24 and 48 h postoperatively. The mean RRA (0.50 ± 0.11) in the final recall radiographs was significantly larger than that in the immediate postoperative radiographs (0.35 ± 0.16) (P = 0.046 < 0.05).
conclusionBased on this study, the ADAB clot shows potential as an alternative scaffold for RET. Because it can be obtained via maxillary terminal alveolar bone paracentesis with mild postoperative pain intensity and successfully promotes root regrowth. However, the coagulation time of ADAB may be longer than that of PVB, and root regrowth outcomes appear to depend on the developmental stage of the tooth. Hence, further clinical trials are necessary to comprehensively evaluate the clinical efficacy of the ADAB clot. CLINICAL RELEVANCE: Compared to autologous platelet concentrates (APCs) derived from PVB, ADAB clots offer advantages in RET, especially in cases where periapical bleeding is insufficient to fill the root canals. ADAB clots can be prepared independently by dentists without the need for a qualified nurse for blood collection or specialized centrifugation equipment. Furthermore, the volume of blood required to fabricate an ADAB clot is less than that needed for APCs from PVB.
Indexed as
Identifiers
39890646What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.