ArticleBMJ case reports2025
Hypothyroid-induced hyponatraemia in a premature infant with a false-negative newborn screening for congenital hypothyroidism.
Article in BMJ case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Approach to the patient: genetics and management of congenital hypothyroidism.The Journal of clinical endocrinology and metabolism · 2026Article
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6 authors.
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Abstract
Worldwide newborn screening (NBS) programmes detect one in 2000-4000 newborns with forms of congenital hypothyroidism (CH). However, some newborns such as premature born babies, are at increased risk for a false-negative test result caused by delayed thyroid-stimulating hormone (TSH) elevation through an immature hypothalamic-pituitary axis. We report a case of a premature newborn in which CH remained undetected. At the age of 3 months cardiorespiratory incidents increased, bradycardia, hypothermia and seizures developed. Investigation revealed severe hypotonic hyponatraemia (85 mmol/L), severe CH (TSH 300 mIU/L, free T4 2 pmol/L), renal insufficiency and metabolic acidosis. High urine osmolality, low urine sodium concentration and an extremely activated renin-angiotensin-aldosterone system suggested a low effective circulating volume. This case report describes hypothyroid-induced hyponatraemia in a premature newborn with a false-negative NBS and thus re-emphasises the importance of repeat screening or repeat thyroid function testing for CH in premature newborns.
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