Evaluation of Inborn Errors of Immunity Among Patients with Opportunistic Pulmonary Infection.

Rachel Husmann, Alice Lehman, Ryan W Nelson, Alexa A Pragman

Abstract readReview

In one paragraph

Review in Clinics in chest medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

CD4Frontiers in cellular and infection microbiology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rachel HusmannDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, 420 Delaware Street Southeast #D416, Minneapolis, MN 55455, USA.

Alice LehmanDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, 420 Delaware Street Southeast #D416, Minneapolis, MN 55455, USA; Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Minnesota, 420 Delaware Street Southeast #850, Minneapolis, MN 55455, USA.

Ryan W NelsonDivision of Rheumatology, Allergy & Immunology, Department of Pediatrics, University of Minnesota, Academic Office Building, 2450 Riverside Avenue South AO-10, Minneapolis, MN 55454, USA; Center for Immunology, University of Minnesota, 2101 6th Street Southeast, Minneapolis, MN 55454, USA.

Alexa A PragmanDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, 420 Delaware Street Southeast #D416, Minneapolis, MN 55455, USA; Division of Infectious Diseases, Department of Medicine, Minneapolis Veterans Affairs Medical Center, 1 Veterans Drive, 111F, Minneapolis, MN 55417, USA. Electronic address: alexa@umn.edu.

Funding

Infectious Disease Training in Clinical InvestigationT32AI055433 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI David R Boulware · 2003 to 2026

$6.1M

Lung resident Treg suppression of Th2 resident memory T cells in allergicasthmaK08AI171176 · NIAID · UNIVERSITY OF MINNESOTA · PI Ryan William Nelson · 2023 to 2026

$780k

CSRD VA I01 CX002130CSRD VA IK2 CX001095NIAID NIH HHS K08 AI171176NIAID NIH HHS T32 AI055433

6 · The paper itself

Abstract

This review of immunocompromised host pneumonia as the result of inborn errors of immunity (IEI) is organized by opportunistic pulmonary pathogen. The authors identify patients who warrant an evaluation for an IEI based on their clinical presentation. Their recommendations are guided by the immune defect(s) associated with each opportunistic pulmonary infection. Physicians without expertise in immunology may begin an evaluation for IEI using the guidance provided here. Comprehensive evaluation by an immunologist may also be warranted in many instances.

Indexed as

Immunocompromised HostOpportunistic InfectionsPneumoniaHumansCellularHumoralImmunityImmunocompromised hostInnateOpportunistic infectionsPneumoniaPrimary immunodeficiency diseases

Identifiers

PMID39890293

DOI10.1016/j.ccm.2024.10.005

PMCPMC11787548

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.