Evidence map›Paper›PMID 39890055›Full record

ArticleMetabolism: clinical and experimental2025

Disrupted metabolic flux balance between pyruvate dehydrogenase and pyruvate carboxylase in human fatty liver.

Jae Mo Park, Sung-Han Lin, Jeannie D Baxter, Crystal E Harrison, Jennine Leary, Corey Mozingo, Jeff Liticker, Craig R Malloy, Eunsook S Jin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism: clinical and experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jae Mo ParkAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA; Department of Biomedical Engineering, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA; Department of Radiology, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA. Electronic address: jaemo.park@utsouthwestern.edu.
Sung-Han LinAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA.
Jeannie D BaxterAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA.
Crystal E HarrisonAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA.
Jennine LearyAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA.
Corey MozingoAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA.
Jeff LitickerAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA.
Craig R MalloyAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA; Department of Radiology, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA; Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA; VA North Texas Healthcare System, Dallas 75216, TX, USA. Electronic address: craig.malloy@utsouthwestern.edu.
Eunsook S JinAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA; Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas 75390, TX, USA. Electronic address: eunsook.jin@utsouthwestern.edu.

Funding

TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9M
Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4M
Pyruvate and acetate metabolism after TBI: implications for cerebral energy metabolismR01NS107409 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PARK, JAE MO · 2020 to 2024
$2.7M
Development of early metabolic imaging biomarkers for muscular dystrophy and cardiomyopathy in patientsR01HL170039 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI PRADEEP P.A. MAMMEN, Jae Mo Park · 2024 to 2026
$2.2M
A Clinical MR Scanner for Imaging Hyperpolarized Carbon-13S10RR029119 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2011 to 2011
$2.2M
A Clinical Polarizer for Carbon-13 (SpinLab)S10OD018468 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2015 to 2015
$1.0M
NCRR NIH HHS S10 RR029119NHLBI NIH HHS R01 HL170039NIBIB NIH HHS P41 EB015891NIBIB NIH HHS P41 EB015908NIDDK NIH HHS P30 DK127984NIH HHS S10 OD018468NINDS NIH HHS R01 NS107409
6 · The paper itself

Abstract

Hepatic metabolism involving pyruvate carboxylase (PC) and pyruvate dehydrogenase (PDH) may be abnormal in fatty livers. In this study, [

Indexed as

Fatty LiverPyruvate CarboxylasePyruvate Dehydrogenase ComplexAdultCarbon IsotopesFemaleGlycerolHumansLactic AcidLiverMaleMiddle AgedPyruvic AcidTriglyceridesCarbon IsotopesGlycerolLactic AcidPyruvate CarboxylasePyruvate Dehydrogenase ComplexPyruvic AcidTriglyceridesFatty liverGlyceroneogenesisHyperpolarizedPyruvate carboxylasePyruvate dehydrogenase

Identifiers

PMID39890055
PMCPMC11955189

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.