Evidence map›Paper›PMID 39889812›Full record

ArticleNeuroImage2025

A Test-Retest Study of Single- and Multi-Delay pCASL for Choroid Plexus Perfusion Imaging in Healthy Subjects Aged 19 to 87 Years.

Zixuan Liu, Qinyang Shou, Kay Jann, Chenyang Zhao, Danny Jj Wang, Xingfeng Shao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zixuan LiuLaboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Qinyang ShouLaboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Kay JannLaboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Chenyang ZhaoLaboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Danny Jj WangLaboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Xingfeng ShaoLaboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: xshao@ini.usc.edu.

Funding

Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic PopulationU01NS100614 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H, RINGMAN, JOHN M · 2023 to 2025
$3.9M
Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic PopulationUF1NS100614 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H, RINGMAN, JOHN M · 2021 to 2021
$2.6M
Imaging Cerebral Small Vessels in Vascular Cognitive Impairment and Dementia (VCID)RF1AG084072 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JIANG, XUEJUAN, SHI, YONGGANG · 2023 to 2023
$2.5M
Laminar Perfusion ImagingR01EB032169 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Danny JJ WANG · 2021 to 2026
$2.5M
Multiband ASL for Neurodevelopment StudyR01EB028297 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WANG, DANNY JJ · 2019 to 2023
$2.2M
Non-invasive MRI mapping of BBB water exchange rate and permeabilityR01NS134712 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Danny JJ WANG · 2024 to 2026
$2.1M
BBB Permeability Imaging in CADASILR01NS114382 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WANG, DANNY JJ · 2020 to 2024
$1.2M
NIA NIH HHS RF1 AG084072NIBIB NIH HHS R01 EB028297NIBIB NIH HHS R01 EB032169NINDS NIH HHS R01 NS114382NINDS NIH HHS R01 NS134712NINDS NIH HHS U01 NS100614NINDS NIH HHS UF1 NS100614
6 · The paper itself

Abstract

There is a growing interest in the choroid plexus (ChP) due to its critical role in cerebrospinal fluid (CSF) production and its involvement in neurodegenerative and cerebrovascular diseases. However, comprehensive studies comparing the accuracy and reliability of single- and multi-PLD (post-labeling delay) arterial spin labeling (ASL) techniques, specifically in relation to the ChP, remain limited. This study systematically evaluated the test-retest reliability and quantification accuracy of cerebral blood flow (CBF) measurements, focusing on the ChP, using single-delay and multi-delay 3D gradient-and-spin echo (GRASE) pseudo-continuous ASL (pCASL) on 28 subjects (aged 19 to 87 years, 14 males/14 females) at 3.0 tesla. Both single-delay (2 s) and 5-PLD (0.5 - 2.5 s) pCASL scans were repeated approximately one week apart with a spatial resolution of 2.5 × 2.5 × 3 mm³. Voxel-wise and regional CBF and arterial transit time (ATT) measurements were compared to assess test-retest reliability, with a particular focus on ChP perfusion changes with age. In this study, 12.15 % of ChP voxels exhibited ATTs longer than 2 s, potentially leading to a significant underestimation of CBF using single-delay ASL. Multi-delay ASL showed improved accuracy in estimating CBF values for the ChP compared to single-delay ASL when ATT > PLD. Additionally, ChP volume (mean ± std = 1.72± 0.85 ml) increased (p < 0.01) and ChP perfusion (43.07±14.18 mL/100 g/min) decreased (p = 0.04) with age. These findings underscore the robustness of multi-delay ASL with model-fitting quantification in assessing ChP perfusion, making it the preferred method for accurate CBF and ATT estimation, particularly in regions with prolonged transit time such as ChP.

Indexed as

Cerebrovascular CirculationChoroid PlexusMagnetic Resonance ImagingPerfusion ImagingAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedReproducibility of ResultsSpin LabelsYoung AdultSpin LabelsAgingArterial spin labeling (ASL)Cerebrospinal fluidChoroid plexusMultiple-delay ASLQuantification accuracySingle-delay ASLTest-retest reliability

Identifiers

PMID39889812
PMCPMC12105218

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.