Evidence map›Paper›PMID 39889456›Full record

ArticlePediatric neurology2025

Preferred Parental Language and Neurodevelopmental Outcomes Among Infants With Acute Provoked Neonatal Seizures in the United States.

Greta S Peng, Karin Halsey, Courtney J Wusthoff, Catherine J Chu, Shavonne L Massey, Monica E Lemmon, Cameron Thomas, Adam L Numis, Giulia M Benedetti, Julie Sturza and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Greta S PengDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Karin HalseyJohns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Courtney J WusthoffDepartment of Neurology, UC Davis Children's Hospital, University of California Davis, Sacramento, California.
Catherine J ChuDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Shavonne L MasseyDepartment of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Neurology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Monica E LemmonDepartments of Pediatrics, Duke University School of Medicine, Durham, North Carolina; Department of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina.
Cameron ThomasDivision of Neurology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.
Adam L NumisDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA; Department of Neurology and Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA.
Giulia M BenedettiDepartment of Pediatrics, University of Michigan, Ann Arbor, MI.
Julie SturzaDepartment of Pediatrics, University of Michigan, Ann Arbor, MI.
Elizabeth E RogersDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Linda S FranckDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA; Department of Family Health Care Nursing, University of California, San Francisco, San Francisco, CA.
Charles E McCullochDepartment of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA.
Janet S SoulDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Renée A ShellhaasDepartment of Neurology, Washington University in St Louis, St Louis, Missouri.
Sonia L BonifacioDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Palo Alto, California.
Hannah C GlassDivision of Neurology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio; Department of Neurology and Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, CA; Department of Family Health Care Nursing, University of California, San Francisco, San Francisco, CA. Electronic address: Hannah.Glass@ucsf.edu.

Funding

Neonatal Seizure Registry Developmental Functional EValuation (NSR-DEV)R01NS111166 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLASS, HANNAH CRANLEY, SHELLHAAS, RENEE A. · 2020 to 2023
$4.6M
NINDS NIH HHS R01 NS111166
6 · The paper itself

Abstract

backgroundParental non-English language preference (NELP) is associated with worse pediatric health outcomes. However, little is known about its relationship with developmental outcomes in infants with neonatal seizures. This study evaluated the relationship between parental NELP and neurodevelopment in a multicenter cohort of infants with neonatal seizures.

methodsInfants in the Neonatal Seizure Registry-II were included. Parental NELP was defined by the use of a professional interpreter for research consent and survey completion. The Warner Initial Developmental Evaluation of Adaptive and Functional Skills (WIDEA-FS) assessment was conducted at age 24 months. Multivariate regression was used to examine the association between parental NELP and WIDEA-FS. Functional developmental impairment was defined as a WIDEA-FS score 2 S.D.s below the normative mean.

resultsAmong 270 infants with neonatal seizures, 15 (6%) had parental NELP. Children with parental NELP had a WIDEA-FS score that was on average 13 points lower than that of infants without parental NELP (95% confidence interval [CI]: -27 to 1, P = 0.08) and over five times the odds of functional developmental impairment (odds ratio 4.9, 95% CI: 1.3 to 18.4, P = 0.017).

conclusionsChildren with parental NELP were more likely to have functional developmental impairment at age 24 months when compared with children without parental NELP. Since parental NELP does not have a biologically plausible impact on neurodevelopment it likely reflects discriminatory experiences that affect developmental opportunities. These findings highlight the importance of identifying social drivers to decrease potential gaps in neurodevelopmental attainment for children with parental NELP.

Indexed as

Child DevelopmentDevelopmental DisabilitiesLanguageNeurodevelopmental DisordersParentsSeizuresChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornMaleRegistriesUnited StatesHealth equityLanguage-related health inequitiesLimited English proficiencyNeonatal seizuresNeurodevelopmentNon-English language preferenceParental language preferenceSpanish language preference

Identifiers

PMID39889456
PMCPMC13354519

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.