Evidence map›Paper›PMID 39889361›Full record

ArticleClinics (Sao Paulo, Brazil)2025

Evaluation of single-dose umbilical cord blood-derived mononuclear cell injection immediately and 7 days after spinal cord trauma in mice.

Alex Oliveira de Araujo, Gustavo Bispo Dos Santos, Raphael Martus Marcon, Maria Helena Alves Nicola, Marcela Saldanha Pereira, Fernando Barbosa Sanchez, Thiego Pedro Freitas Araujo, Alexandre Fogaça Cristante

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Article in Clinics (Sao Paulo, Brazil), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Alex Oliveira de AraujoDepartment of Orthopedic Surgery, Rede SARAH de Hospitais de Reabilitação, (SMHS), Brasília, DF, Brazil. Electronic address: alexiotfmusp@gmail.com.
Gustavo Bispo Dos SantosDepartment of Orthopedic Surgery, Instituto de Ortopedia e Traumatologia da Universidade de São Paulo, São Paulo, SP, Brazil.
Raphael Martus MarconDepartment of Orthopedic Surgery, Instituto de Ortopedia e Traumatologia da Universidade de São Paulo, São Paulo, SP, Brazil.
Maria Helena Alves NicolaCryopraxis Cryobiology, Espírito Santo do Pinhal, SP, Brazil.
Marcela Saldanha PereiraCryopraxis Cryobiology, Espírito Santo do Pinhal, SP, Brazil.
Fernando Barbosa SanchezDepartment of Orthopedic Surgery, Instituto de Ortopedia e Traumatologia da Universidade de São Paulo, São Paulo, SP, Brazil.
Thiego Pedro Freitas AraujoDepartament of Orthopedic Surgery, Hospital Sírio Libanês, Brasília, DF, Brazil.
Alexandre Fogaça CristanteDepartment of Orthopedic Surgery, Instituto de Ortopedia e Traumatologia da Universidade de São Paulo, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designExperimental study utilizing a standardized Balb C mouse model.

objectivesEvaluate histological changes and motor function recovery in the acute and subacute phases of Spinal Cord Injury (SCI) in mice using human Umbilical cord blood-derived mononuclear cells.

methodsForty mice were divided into five groups, with two receiving human Umbilical cord blood-derived mononuclear cells immediately after SCI and after 7 days, and three control groups. Motor assessment utilized BMS, MFS, and horizontal plane scales over six weeks. Necropsy evaluated macroscopic and histological spinal cord changes.

resultsHistologically, Umbilical cord blood-derived mononuclear cells-treated groups exhibited significant reductions in necrosis, hemorrhage, and degeneration compared to controls. Motor recovery showed partial improvement across all groups, with no statistically significant differences in scales between intervention and control groups.

conclusionsIn the acute phases of SCI, Umbilical cord blood-derived mononuclear cells applied directly to Balb C mice lesions demonstrated histological improvement but played a limited role in functional enhancement. The study highlights distinctions in the treatment's efficacy, potentially related to these cells' diverse differentiation capacities and intrinsic properties.

Indexed as

Cord Blood Stem Cell TransplantationFetal BloodLeukocytes, MononuclearSpinal Cord InjuriesAnimalsDisease Models, AnimalFemaleHumansMiceMice, Inbred BALB CRecovery of FunctionTime FactorsTreatment OutcomeHistopathological assessmentMononuclear stem cellsMotor assessmentSpinal cord injuryUmbilical cord blood-derived mononuclear cell

Identifiers

PMID39889361
PMCPMC11833352

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.