Evidence map›Paper›PMID 39889002›Full record

ArticleScience advances2025

Touch-evoked traveling waves establish a translaminar spacetime code.

Daniel L Gonzales, Hammad F Khan, Hayagreev V S Keri, Saumitra Yadav, Christopher Steward, Lyle E Muller, Scott R Pluta, Krishna Jayant

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  6. Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Distinct laminar origins of sensory-evoked high-gamma and low-frequency ECoG signals revealed by optogenetics.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
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  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Daniel L GonzalesWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-4120-9383
Hammad F KhanWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0001-8126-7564
Hayagreev V S KeriWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0009-0008-0740-2797
Saumitra YadavWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0001-6301-5734
Christopher StewardDepartment of Computer Science, Western University, London, ON, Canada.ORCID 0009-0009-5098-8305
Lyle E MullerDepartment of Applied Mathematics, Western University, London, ON, Canada.ORCID 0000-0001-5165-9890
Scott R PlutaDepartment of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-3057-8095
Krishna JayantWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0003-4353-6123

Funding

Massively scalable 3D electrophysiology and two-photon imaging in freely-moving animalsDP2MH136494 · NIMH · PURDUE UNIVERSITY · PI Krishna jayant · 2023 to 2026
$2.2M
Interdisciplinary Training in Auditory NeuroscienceT32DC016853 · NIDCD · PURDUE UNIVERSITY · PI Edward Bartlett, Michael G Heinz · 2018 to 2026
$1.5M
The Nanoneedle Net: A flexible and transparent 3D nanoelectrode array for mapping intracellular dendritic dynamics at the cortical surfaceR21EB029740 · NIBIB · PURDUE UNIVERSITY · PI JAYANT, KRISHNA · 2020 to 2022
$606k
NIBIB NIH HHS R21 EB029740NIDCD NIH HHS T32 DC016853NIMH NIH HHS DP2 MH136494
6 · The paper itself

Abstract

Linking sensory-evoked traveling waves to underlying circuit patterns is critical to understanding the neural basis of sensory perception. To form this link, we performed simultaneous electrophysiology and two-photon calcium imaging through transparent NeuroGrids and mapped touch-evoked traveling waves and underlying microcircuit dynamics. In awake mice, both passive and active whisker touch elicited traveling waves within and across barrels, with a fast early component followed by a late wave that lasted hundreds of milliseconds poststimulus. Notably, late waves were modulated by perceived value and predicted behavioral choice in a two-whisker discrimination task. We found that the late wave feature was (i) modulated by motor feedback, (ii) differentially engaged a sparse ensemble reactivation pattern across layer 2/3, which a balanced-state network model reconciled via feedback-induced inhibitory stabilization, and (iii) aligned to regenerative layer 5 apical dendritic Ca

Indexed as

Somatosensory CortexTouchAnimalsCalciumMaleMiceVibrissaeCalcium

Identifiers

PMID39889002
PMCPMC11784861

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.