Evidence map›Paper›PMID 39888991›Full record

ArticleScience advances2025

DNA methylation-based age prediction and sex-specific epigenetic aging in a lizard with female-biased longevity.

Ethan P Shealy, Tonia S Schwartz, Robert M Cox, Aaron M Reedy, Benjamin B Parrott

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ethan P ShealySavannah River Ecology Laboratory, University of Georgia, Aiken, SC 29802, USA.ORCID 0000-0002-5613-3756
Tonia S SchwartzDepartment of Biological Sciences, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0002-7712-2810
Robert M CoxDepartment of Biology, University of Virginia, Charlottesville, VA 22904, USA.ORCID 0000-0001-8325-111X
Aaron M ReedyDataClassroom, 1022 Cottonwood Rd, Charlottesville, VA 22901, USA.ORCID 0000-0001-8835-0811
Benjamin B ParrottSavannah River Ecology Laboratory, University of Georgia, Aiken, SC 29802, USA.

Funding

A new vertebrate model to study the role of growth factors IGF1 and IGF2 in sex dimorphism of longevity and aging.R15AG064655 · NIA · AUBURN UNIVERSITY AT AUBURN · PI SCHWARTZ, TONIA S · 2019 to 2019
$448k
Integrating environment-by-epigenome interactions into a tractable model of epigenetic agingR56AG078336 · NIA · UNIVERSITY OF GEORGIA · PI PARROTT, BENJAMIN BARROW · 2022 to 2022
$273k
NIA NIH HHS R15 AG064655NIA NIH HHS R56 AG078336
6 · The paper itself

Abstract

Sex differences in life span are widespread across animal taxa, but their causes remain unresolved. Alterations to the epigenome are hypothesized to contribute to vertebrate aging, and DNA methylation-based aging clocks allow for quantitative estimation of biological aging trajectories. Here, we investigate the influence of age, sex, and their interaction on genome-wide DNA methylation patterns in the brown anole (

Indexed as

AgingDNA MethylationEpigenesis, GeneticLizardsLongevityAnimalsFemaleMaleSex CharacteristicsSex Factors

Identifiers

PMID39888991
PMCPMC11784858

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.