Accelerated dynamic magnetic resonance imaging from Spatial-Subspace Reconstructions (SPARS).

Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) ideally requires a high spatial and a high temporal resolution, but hardware limitations prevent acquisitions from achieving both simultaneously-either high temporal resolution is exchanged for spatial resolution, or vice versa. Even state-of-the-art image reconstruction techniques that infer missing data in a sparse acquisition space cannot recover the loss of spatial detail, especially at high temporal acceleration rates. The purpose of this paper is to introduce the concept of spatial subspace reconstructions (SPARS) and demonstrate its ability to reconstruct high spatial resolution dynamic images from as few as one acquired k-space spoke per time frame in a dynamic series. Briefly, a low-temporal-high-spatial resolution organization of the acquired raw data is used to estimate the basis vectors of the spatial subspace in which the high-temporal-high-spatial ground truth data resides. This subspace is then used to estimate entire images from single k-space spokes. In both simulated and human in-vivo data, the proposed SPARS reconstruction method outperformed standard GRASP and GRASP-Pro reconstruction, providing a shorter reconstruction time and yielding higher accuracy from both a spatial and temporal perspective.