ArticleAIDS (London, England)2025
Clinical and sociodemographic characteristics of Alzheimer's disease and related dementias among people with HIV.
Article in AIDS (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Update on neurological complications of HIV.Current opinion in HIV and AIDS · 2025Review
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8 authors.
Funding
Abstract
introductionAlzheimer's disease and related dementias (AD/ADRD) continue to be a public health challenge. People with HIV (PWH) are at risk for neurocognitive disorders and may be at risk for AD/ADRD. However, studies examining clinical and sociodemographic factors associated with AD/ADRD among PWH are lacking. Therefore, the aim of this cross-sectional study was to determine the association between selected sociodemographic (age, gender, race, and rurality) and clinical (depression and encephalopathy) factors with AD/ADRD among PWH.
methodsData were obtained from the South Carolina Revenue and Fiscal Affairs (RFA) Office and the South Carolina Alzheimer's Disease Registry ( N = 13 390). Multivariable logistic regression models were used to determine the association between age, gender, race, rurality, depression, and encephalopathy, and AD/ADRD among PWH.
resultsAmong the study population ( N = 13 390), 5% ( n = 601) were found to have AD/ADRD. There was a dose-response relationship between age group and AD/ADRD whereas the age group increased, the association increased. For example, those who were aged 80 years and older were 80 times more likely to have AD/ADRD compared to those aged 18-29 years [adjusted odds ratio (aOR): 80.4; 95% confidence interval (CI): 40.2-160.8]. Additionally, male sex (aOR: 1.3; 95% CI: 1.9-1.6) and encephalopathy (aOR: 2.4; 95% CI: 1.9-3.2) were positively associated with AD/ADRD for PWH.
conclusionAD/ADRD interventions may be warranted among PWH, especially among older adults, men, and those with encephalopathy. Future studies should examine potential pathways between clinical and sociodemographic characteristics and AD/ADRD among PWH.
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