Trial reportPhotodermatology, photoimmunology & photomedicine2025
Lemon Balm (Melissa officinalis L.) Leaf Extract Promotes Endo180 Production in Dermal Fibroblasts and has Antiwrinkle Effect on Human Skin.
Trial report in Photodermatology, photoimmunology & photomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Review
- Mannosylated nanocarriers: a precision targeting strategy for tumors and infectious diseases.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe collagen receptor Endo180 participates in extracellular matrix remodeling by clearing the pericellular environment and recognizing and internalizing collagen degradation products. In photoaged skin, Endo180 expression in fibroblasts is decreased, and collagen fragments accumulate in the pericellular environment, leading to a decrease in type I collagen production and an increase in matrix metalloproteinase 1 production. This suggests that a decrease in Endo180 production may promote wrinkle formation by decreasing the dermal collagen fibril volume. Therefore, this study aimed to identify materials that promote Endo180 production in vitro and investigate whether promoting Endo180 production could prevent and improve wrinkles in vivo.
methodsEndo180 gene expression and protein production in fibroblasts were evaluated after screening 71 natural extracts. The conditioned medium of UVB-irradiated keratinocytes and Endo180 production-promoting extract were added to fibroblasts, and Endo180 and type I collagen production were evaluated. In a double-blind, randomized, placebo-controlled study, a cream formulated with an Endo180 production-promoting extract or placebo was topically administered to each side of the face of 20 healthy women twice daily for 8 weeks.
resultsScreening results showed that 50 μg/mL of lemon balm (Melissa officinalis L.) leaf extract (MOLE) resulted in the highest levels of both Endo180 mRNA and protein at 178.1% and 127.4%, respectively. Its major component rosmarinic acid also promoted Endo180 production by 143.9% at a concentration of 20 μg/mL. MOLE at 200 μg/mL almost completely inhibited the decrease in Endo180 and type I collagen production in UVB-irradiated keratinocyte-conditioned medium. Furthermore, eye-corner wrinkles were reduced by treatment with the MOLE formulation compared to that in response to the placebo formulation.
conclusionsMOLE may act as an antiwrinkle agent that inhibits the decline in collagen levels by promoting Endo180 production.
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