Evidence map›Paper›PMID 39888424›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Whole-body PET imaging of simian immunodeficiency virus using gp120-targeting probes fails to reveal regions of specific uptake in rhesus macaques.

Sharat Srinivasula, Insook Kim, Hyukjin Jang, Paula Degrange, Heather Brown, Viviana Dalton, Yunden Badralmaa, Ven Natarajan, Brad Long, Jorge A Carrasquillo and 1 more

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Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sharat SrinivasulaAIDS Imaging Research Section, Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Insook KimAIDS Imaging Research Section, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Hyukjin JangAIDS Imaging Research Section, Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Paula DegrangeAIDS Imaging Research Section, Laulima Government Solutions, Integrated Research Facility, NIAID, NIH, Frederick, MD, USA.
Heather BrownAIDS Imaging Research Section, Laulima Government Solutions, Integrated Research Facility, NIAID, NIH, Frederick, MD, USA.
Viviana DaltonAIDS Imaging Research Section, Laulima Government Solutions, Integrated Research Facility, NIAID, NIH, Frederick, MD, USA.
Yunden BadralmaaLaboratory of Molecular Cell Biology, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Ven NatarajanLaboratory of Molecular Cell Biology, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Brad LongAIDS Imaging Research Section, Laulima Government Solutions, Integrated Research Facility, NIAID, NIH, Frederick, MD, USA.
Jorge A CarrasquilloMolecular Imaging Program, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA.
Michele Di MascioAIDS Imaging Research Section, Division of Clinical Research, NIAID, NIH, Poolesville, MD, USA. mdimascio@niaid.nih.gov.ORCID 0000-0001-6609-9689

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFollowing the initial reports demonstrating the feasibility of immunoPET imaging of simian immunodeficiency virus (SIV) using gp120-targeting monoclonal antibodies in non-human primates, replication efforts of the imaging system in human immunodeficiency virus (HIV)-infected individuals have yielded conflicting results. Herein, we used two anti-gp120 antibodies, 7D3 and ITS103.01LS-F(ab')

methodsThe binding affinity estimates of

resultsDespite the demonstrated nanomolar affinity of [

conclusionThe overall absence of specific uptake suggests inadequate binding potential (ligand affinity x target molarity) for these probes to effectively image SIV or HIV in-vivo, warranting further investigation into the lack of reproducibility observed with earlier non-human primate SIV imaging and conflicting human studies.

Indexed as

Positron-Emission TomographySimian Immunodeficiency VirusWhole Body ImagingAnimalsAntibodies, MonoclonalBiological TransportMacaca mulattaMembrane GlycoproteinsRadioisotopesTissue DistributionViral Envelope ProteinsZirconiumAntibodies, Monoclonalgp120 protein, Simian immunodeficiency virusMembrane GlycoproteinsRadioisotopesViral Envelope ProteinsZirconiumZirconium-897D3Endogenous antibodiesImmunoPETITS103ReproducibilityRhesus macaques

Identifiers

PMID39888424
PMCPMC12119729

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.