Evidence map›Paper›PMID 39888382›Full record

ArticleAbdominal radiology (New York)2025

Intracellular enhancement technique for gadoxetic acid-enhanced hepatobiliary-phase magnetic resonance imaging: evaluation of hepatic function.

Dara Fonseca, Yuko Nakamura, Toru Higaki, Shogo Maeda, Takashi Nishihara, Yoshitaka Bito, Masahiro Takizawa, Shota Kondo, Ryo Higashino, Shintaro Morishita and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Abdominal radiology (New York), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Quantitative Assessment of Liver Function Using the Liver Enhancement Ratio on Gadoxetic Acid-Enhanced Magnetic Resonance Imaging in Chronic Liver Disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Dara FonsecaHiroshima University, Hiroshima City, Japan.
Yuko NakamuraHiroshima University, Hiroshima City, Japan. yukon@hiroshima-u.ac.jp.
Toru HigakiHiroshima University, Hiroshima City, Japan.
Shogo MaedaHiroshima University, Hiroshima City, Japan.
Takashi NishiharaFUJIFILM Corporation, Shintoyofuta, Kashiwa City, Japan.
Yoshitaka BitoFUJIFILM Corporation, Shintoyofuta, Kashiwa City, Japan.
Masahiro TakizawaFUJIFILM Corporation, Shintoyofuta, Kashiwa City, Japan.
Shota KondoHiroshima University, Hiroshima City, Japan.
Ryo HigashinoHiroshima University, Hiroshima City, Japan.
Shintaro MorishitaHiroshima University, Hiroshima City, Japan.
Yuji AkiyamaHiroshima University Hospital, Hiroshima City, Japan.
Shingo FukumaHiroshima University, Hiroshima City, Japan.
Tomokazu KawaokaHiroshima University, Hiroshima City, Japan.
Masataka TsugeHiroshima University, Hiroshima City, Japan.
Shiro OkaHiroshima University, Hiroshima City, Japan.
Kazuo AwaiHiroshima University, Hiroshima City, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the utility of intracellular enhancement (ICE) technique which suppresses signals from the extracellular space for the evaluation of hepatic function on gadoxetic acid-enhanced hepatobiliary-phase (HBP) images.

methodsWe subjected 67 patients with suspected neoplastic hepatic lesions to gadoxetic acid-enhanced HBP imaging with and without ICE [i-HBP, conventional-HBP (c-HBP)]. A radiologist calculated the liver/spleen contrast (LSC) [LSC = signal intensity (SI) of liver/SI of spleen]. Receiver-operating analysis was used to evaluate the diagnostic value of the LSC on i-HBP- (i-LSC) and c-HBP images (c-LSC) to differentiate between Child-Pugh classes A and B.

resultsOf the 67 patients, 57 were in Child-Pugh class A and 10 were in class B. For their differentiation, the area under the curve value of i-LSC was higher than of c-LSC (0.81 vs. 0.68).

conclusionsICE technique can improve the accuracy of estimating hepatic function on HBP images.

Indexed as

Contrast MediaGadolinium DTPAImage EnhancementLiver NeoplasmsMagnetic Resonance ImagingAdultAgedAged, 80 and overFemaleHumansLiverLiver Function TestsMaleMiddle AgedRetrospective StudiesContrast MediaGadolinium DTPAgadolinium ethoxybenzyl DTPAGadoxetic acidHepatic functionIntracellular enhancement techniqueMagnetic resonance imagingMotion-sensitized driven equilibrium pulse

Identifiers

PMID39888382
PMCPMC12267321

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.