Evidence map›Paper›PMID 39888273›Full record

ArticleFEBS open bio2025

Tryptophan-sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin-producing cells.

Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando-Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yoko UedaDepartment of Pharmacotherapeutics, School of Pharmaceutical Science, Wakayama Medical University, Wakayama, Japan.ORCID https://orcid.org/0009-0008-7009-9970
Hiroshi IwakuraDepartment of Pharmacotherapeutics, School of Pharmaceutical Science, Wakayama Medical University, Wakayama, Japan.ORCID https://orcid.org/0000-0001-8033-0736
Takuya EnshoDepartment of Pharmacotherapeutics, School of Pharmaceutical Science, Wakayama Medical University, Wakayama, Japan.
Mika Bando-ShimizuThe First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
Asako DoiThe First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
Norihiko MatsutaniThe First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
Shuhei MoritaThe First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
Hidefumi InabaThe First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
Hiroyuki AriyasuThe First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
Naoki FukudaSecond Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Keiji HayataSecond Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Toshiyasu OjimaSecond Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Masahiro NishiThe First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
Taka-Aki MatsuokaThe First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
Hiroki YamaueSecond Department of Surgery, Wakayama Medical University, Wakayama, Japan.
Takashi AkamizuThe First Department of Medicine, Wakayama Medical University, Wakayama, Japan.

Funding

Japan Society for the Promotion of Science JP20K11514Japan Society for the Promotion of Science JP23K16776
6 · The paper itself

Abstract

GPR142 is a tryptophan-sensing receptor that has been implicated in the regulation of inflammation. In this study, we investigated the relationships between inflammatory cytokine and GPR142 expression by using cellular, animal models, and human stomach samples. We found that addition of TNF-α, IL-6, and IL-1β into the culture of ghrelin-producing cell line, MGN3-1 cells, increased GPR142 mRNA expression levels. Lipopolysaccharide (LPS) injection to mice significantly increased GPR142 expression in the stomach, confirming the results observed in the cellular model. GPR142 mRNA expression levels in the stomach samples of morbidly obese patients were positively correlated with TNF-α, IL-6, and IL-1β mRNA levels. Taken together our results suggest that GPR142 expression is under the direct control of proinflammatory cytokines and support further investigation of GPR142 potential roles in inflammation.

Indexed as

CytokinesGhrelinReceptors, G-Protein-CoupledAnimalsCell LineFemaleHumansInflammationLipopolysaccharidesMaleMiceMice, Inbred C57BLObesity, MorbidTryptophanCytokinesGhrelinLipopolysaccharidesReceptors, G-Protein-CoupledTryptophanghrelinGPR142proinflammatory cytokinestryptophan

Identifiers

PMID39888273
PMCPMC12051013

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.