Evidence map›Paper›PMID 39888272›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Mitochondrial Protein MjEF-Tu is Secreted into Host Plants by Nematodes Eliciting Immune Signaling and Resistance.

Borong Lin, Shaozhen Huang, Zhiwen Li, Qiuling Huang, Handa Song, Tianyi Fang, Jinling Liao, Godelieve Gheysen, Kan Zhuo

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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Borong LinCollege of Plant Protection, South China Agricultural University, Guangzhou, 510642, China.
Shaozhen HuangCollege of Plant Protection, South China Agricultural University, Guangzhou, 510642, China.
Zhiwen LiCollege of Plant Protection, South China Agricultural University, Guangzhou, 510642, China.
Qiuling HuangCollege of Plant Protection, South China Agricultural University, Guangzhou, 510642, China.
Handa SongCollege of Plant Protection, South China Agricultural University, Guangzhou, 510642, China.
Tianyi FangCollege of Plant Protection, South China Agricultural University, Guangzhou, 510642, China.
Jinling LiaoCollege of Plant Protection, South China Agricultural University, Guangzhou, 510642, China.
Godelieve GheysenDepartment of Biotechnology, Ghent University, Ghent, 9000, Belgium.
Kan ZhuoCollege of Plant Protection, South China Agricultural University, Guangzhou, 510642, China.ORCID https://orcid.org/0000-0002-5688-3354

Funding

Key Industry Innovation Chain of Shaanxi 2024RS-CXTD-73National Key R&D Program of China 2023YFD1400400National Natural Science Foundation of China 31772136National Natural Science Foundation of China 31972246National Natural Science Foundation of China 32072397
6 · The paper itself

Abstract

Little is known about plant-parasitic animal-derived pathogen-associated molecular pattern (PAMP)/ pattern-recognition receptor (PRR) pairs. Additionally, mitochondrial proteins have not previously been reported to be secreted into hosts by pathogens. Here, it is found that the Meloidogyne javanica elongation factor thermo unstable (EF-Tu) (MjEF-Tu) located in the nematode mitochondria is up-regulated and secreted into the host plant during nematode parasitism. MjEF-Tu interacts with the PRR Arabidopsis thaliana EF-Tu receptor (AtEFR), triggering the plant hallmark defence responses mediated by AtEFR. An 18-aa sequence (Nelf18) in the N terminus of the nematode EF-Tu contributes to the immunogenic activity. M. javanica water extract and mitochondrial extract also induce plant immunity sensed by AtEFR, owing to the presence of MjEF-Tu. In addition, Nelf18 enhances plant resistance to nematode, virus, and bacterial infections depending on AtEFR. These findings first demonstrate that mitochondrial proteins from pathogens can be secreted into hosts and function as a cross-kingdom signal and identified the first plant-parasitic animal-derived proteinaceous PAMP/PRR pair, providing novel insights into host-pathogen interactions.

Indexed as

ArabidopsisMitochondrial ProteinsNematodaPeptide Elongation Factor TuPlant DiseasesPlant ImmunityTylenchoideaAnimalsArabidopsis ProteinsDisease ResistanceHelminth ProteinsHost-Parasite InteractionsMitochondriaSignal TransductionArabidopsis ProteinsHelminth ProteinsMitochondrial ProteinsPeptide Elongation Factor TuMitochondrial proteinNematodePAMPsPAMP‐triggered immunity

Identifiers

PMID39888272
PMCPMC11923865

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.