Evidence map›Paper›PMID 39887960›Full record

ArticleAdvanced biology2025

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer.

Sharda Yadav, Sanjaya Kc, Mark A T Blaskovich, Cu-Tai Lu, Alfred K Lam, Nam-Trung Nguyen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sharda YadavQueensland Micro- and Nanotechnology Centre, Nathan Campus, Griffith University, Brisbane, QLD, 4111, Australia.ORCID https://orcid.org/0000-0002-5838-2270
Sanjaya KcInstitute of Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4067, Australia.
Mark A T BlaskovichInstitute of Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4067, Australia.ORCID https://orcid.org/0000-0001-9447-2292
Cu-Tai LuSchool of Medicine and Dentistry, Griffith University, Southport, QLD, 4222, Australia.
Alfred K LamSchool of Medicine and Dentistry, Griffith University, Southport, QLD, 4222, Australia.ORCID https://orcid.org/0000-0003-2771-564X
Nam-Trung NguyenQueensland Micro- and Nanotechnology Centre, Nathan Campus, Griffith University, Brisbane, QLD, 4111, Australia.ORCID https://orcid.org/0000-0003-3626-5361

Funding

ARC Laureate Fellowship FL230100023
6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a leading cause of cancer-related deaths, creating an urgent need for innovative diagnostic solutions. Mechanobiology, a cutting-edge field that investigates how physical forces influence cell behavior, is now revealing new insights into cancer progression. This research focuses on two crucial players: RhoA and Rac1, small yet powerful proteins that regulate the structure and movement of cancer cells. RhoA controls cell adhesion and migration, while Rac1 drives cell movement and invasion. As CRC tumors grow and reshape the colon's mechanical environment, these pathways become disrupted, accelerating cancer progression. Examining the level of RhoA and Rac1 in CRC clinical samples under mechanical strain reveals their potential as diagnostic markers. Tracking the activity of these proteins can unlock valuable insights into cancer cell dissemination, offering new avenues for understanding and diagnosing CRC. This approach holds promise for earlier detection and better outcomes by offering key insights for more effective diagnostic strategies.

Indexed as

Colorectal NeoplasmsMechanotransduction, Cellularrac1 GTP-Binding ProteinrhoA GTP-Binding ProteinCell AdhesionCell MovementHumansrac1 GTP-Binding ProteinRAC1 protein, humanrhoA GTP-Binding ProteinRHOA protein, humancolorectal cancer (CRC)mechanical strainmechanotransductionRhoA and Rac1tumor microenvironment

Identifiers

PMID39887960
PMCPMC12365731

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.