Evidence map›Paper›PMID 39887942›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Nanotherapies Based on ROS Regulation in Oral Diseases.

Xin Luo, Yanli Zhang, Yuting Zeng, Dehong Yang, Zhiyan Zhou, Ziting Zheng, Ping Xiao, Xian Ding, Qianlin Li, Jiaping Chen and 4 more

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Biomaterial-based therapeutic strategies for oral submucous fibrosis.Frontiers in cell and developmental biology · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Nanotherapies Based on ROS Regulation in Oral Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xin LuoDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yanli ZhangStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, China.
Yuting ZengDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Dehong YangDepartment of Orthopedics Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.ORCID https://orcid.org/0000-0001-7896-8474
Zhiyan ZhouDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Ziting ZhengDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Ping XiaoDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xian DingDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Qianlin LiDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Jiaping ChenDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Qianwen DengDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Xincen ZhongDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Sijie QiuDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Wenjuan YanDepartment of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.ORCID https://orcid.org/0000-0002-5761-5423

Funding

National Natural Science Foundation of China 82171573National Natural Science Foundation of China 82271616Natural Science Foundation of Guangdong Province 2022A1515012435President Foundation of Nanfang Hospital, Southern Medical University 2023A047President Foundation of Nanfang Hospital, Southern Medical University 2023B030Southern Hospital "Clinical Research Project" 2018CR018Southern Medical University College Students' Innovative Entrepreneurial Training Plan Program S202312121168
6 · The paper itself

Abstract

Oral diseases rank among the most prevalent clinical conditions globally, typically involving detrimental factors such as infection, inflammation, and injury in their occurrence, development, and outcomes. The concentration of reactive oxygen species (ROS) within cells has been demonstrated as a pivotal player in modulating these intricate pathological processes, exerting significant roles in restoring oral functionality and maintaining tissue structural integrity. Due to their enzyme-like catalytic properties, unique composition, and intelligent design, ROS-based nanomaterials have garnered considerable attention in oral nanomedicine. Such nanomaterials have the capacity to influence the spatiotemporal dynamics of ROS within biological systems, guiding the evolution of intra-ROS to facilitate therapeutic interventions. This paper reviews the latest advancements in the design, functional customization, and oral medical applications of ROS-based nanomaterials. Through the analysis of the components and designs of various novel nanozymes and ROS-based nanoplatforms responsive to different stimuli dimensions, it elaborates on their impacts on the dynamic behavior of intra-ROS and their potential regulatory mechanisms within the body. Furthermore, it discusses the prospects and strategies of nanotherapies based on ROS scavenging and generation in oral diseases, offering alternative insights for the design and development of nanomaterials for treating ROS-related conditions.

Indexed as

Mouth DiseasesNanomedicineNanostructuresReactive Oxygen SpeciesAnimalsHumansReactive Oxygen Speciesendogenous and exogenous stimuli‐responsivenanorobotnanotherapiesnanozymesoral diseasereactive oxygen species (ROS)

Identifiers

PMID39887942
PMCPMC11884622

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.