ArticleActa paediatrica (Oslo, Norway : 1992)2025
Employing a Haemodynamic Score to Predict Acute Kidney Injury in Infants With Patent Ductus Arteriosus.
Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026Review
- Assessment of Kidney Function and Acute Kidney Injury following Transcatheter Patent Ductus Arteriosus Closure in Preterm Infants.American journal of perinatology · 2026Article
- Understanding the Impact of Patent Ductus Arteriosus and Treatment Strategies on Acute Kidney Injury in Preterm Infants.American journal of perinatology · 2026Review
- Stealing nephrons-a review on how patent ductus arteriosus physiology impacts neonatal kidney health.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimThis study hypothesised that infants with a haemodynamically significant patent ductus arteriosus (hsPDA) as defined by a validated score have a higher incidence of acute kidney injury (AKI).
methodsA retrospective study was conducted including infants < 29 weeks' gestation, born at the Rotunda Hospital. The El-Khuffash patent ductus arteriosus (PDA) severity score was applied following an echocardiographic assessment. Mann Whitney-U and χ
resultsWe report a cohort of n = 86 infants with PDA of a mean (standard deviation) gestation of 27 (1) weeks and birth weight of 957 g (235 g). Ten (11.6%) of infants developed AKI. Birth weight, gestation, death-by-discharge, high-risk PDA score, PDA treatment, and ibuprofen receipt were associated with AKI. The presence of a high-risk PDA score was independently associated with the occurrence of AKI. Therapeutic intervention and ibuprofen use proved significant in their associations with AKI.
conclusionA high-risk El-Khuffash PDA score is predictive of AKI in our cohort. Ductal diameter in isolation is ineffective as a measure of haemodynamic significance in the context of AKI prediction. Both PDA treatment and ibuprofen-use are associated with an increased risk of AKI. Further work to validate the use of this score for AKI prediction is warranted.
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